therosclerosis is increasing among Japanese because of their changing lifestyle.1 Carotid ultrasound examination is a good non-invasive method of detecting atherosclerosis by measuring the intima–media thickness (IMT),2 plaque number (PN) and plaque score (PS).3 Atherosclerosis of the carotid artery is related with not only coronary artery disease (CAD),4,5 but also systemic atherosclerosis. Ho...

(MHC) control to present autoantigens, antigenic mimicry, altered proteins of the host, apoptosis and aging [1]. Beside this, several genetic factors and loci like non-HLA genes and autoimmune susceptibility loci, tumor necrosis factor-alpha (TNF-α) and forkhead box P3 (FOXP3) have been associated with susceptibility to autoimmune diseases [2]. Some common autoimmune diseases are rheumatoid art...

Background Coronary heart disease (CHD) is among the leading causes of death in Kuwait. This case-control study investigated the genetic association of APOB rs11279109 with CHD in Kuwaitis. Methods The polymorphism was genotyped in 734 Kuwaiti samples by direct amplification. Statistical analysis with genetic modeling was used to assess its association with CHD. Results A statistically sign...

Background & Aims of the Study: Oxidative stress increases platelet-derived growth factor (PDGF) gene expression in endothelial cells that contributes to vascular dysfunction and atherosclerosis. Oxidative stress generates by dys-regulated redox balance between ROS producing systems and antioxidant systems. Also, Curcumin (Cur) as a main part of tur...

background & aims of the study: oxidative stress increases platelet-derived growth factor (pdgf) gene expression in endothelial cells that contributes to vascular dysfunction and atherosclerosis. oxidative stress generates by dys-regulated redox balance between ros producing systems and antioxidant systems. also, curcumin (cur) as a main part of turmeric has anti- inflammatory, antioxidant, ant...

Background: Purinergic receptors can be divided into adenosine (P1) and adenosine 5’-triphosphate (ATP) (P2) receptors, which play crucial roles in regulating vessel tone, arthrosclerosis, myocardial preconditioning and heart function. However, the relationship of plasma nucleotides with coronary artery disease (CAD) and heart function have not been reported. Methods and results: Total 97 patie...

Systemic lupus erythematosus (SLE) is a disease that mostly affects women. Accelerated atherosclerosis is a high-risk factor associated with SLE patients. SLE associated with cardiovascular disease is one of the most important causes of death. In this study, we demonstrated that Lactobacillus paracasei GMNL-32 (GMNL-32), a probiotic species, exhibits anti-fibrosis and anti-apoptotic effects on ...

Subclavian Artery Thrombosis (SAT) typically arises secondary to some form of injuries and arthrosclerosis. The contributing factors are coagulopathies and emboli. And, the conserving blood is naturally reflowed from circle of Willis. A cold, painful, cyanosis, and pulseless upper extremity are proved as the symptoms. Recently, a 42-years-old smoker, diabetic, and hyperlipidemic woman was admit...

BACKGROUND We compared the type and duration of diabetes mellitus (DM), patient demography, high sensitivity C-reactive protein (hsCRP), Homocysteine and other variables with IMT, to determine if these markers were correlated in diabetes (in whom technetium myocardial perfusion scan were negative) and would it be appropriate biomarkers for arthrosclerosis detection in this group of diabetics. ...