introduction: cell culture is a process in which the cells ware isolated from original tissue, dispersed in liquid media and then placed in culture plate where the cells adhere together and propagate. today, this method is used for assessment of cell toxicity, its mechanisms and effect of different compounds on intracellular components. methods: clonogenic assay was used for assessment of cell ...

This work investigates arsenic mobility, bioavailability and toxicity in marine port sediments using chemical sequential extraction and laboratory toxicity tests. Sediment samples were collected from two different Mediterranean ports, one highly polluted with arsenic and other inorganic and organic pollutants (Estaque port (EST)), and the other one, less polluted, with a low arsenic content (Sa...

Background: Arsenic toxicity as a result of consumption of hair removal agent has been rarely seen in last few years in comparison with the past. Case Presentation: In this case report, we presented a middle age woman referred to medical toxicology department due to epigastric pain and diarrhea following ingestion of hair removal agent. Urinary test for arsenic was positive. ECG changes and ele...

arsenic is one of the heavy metals and nearly all its compounds, especially organic compounds, are toxic. the wide spectrum of diseases caused by this element has led to evaluation of the toxicity of different arsenic species and identification of the major natural and anthropogenic pollution sources of it in the nature. mining activities are among the main sources of anthropogenic pollution of...

Introduction: Arsenic is a highly toxic element that is widely distributed in environment. Antioxidants depletion and oxidative stress is now considered as one of the possible mechanisms of arsenic-induced toxicity. N-acetylcysteine (NAC) and Curcumin (Cur) are potential antioxidants that can compensate the depletion of antioxidants. This study aimed to compare the hepatoprotective effect of Cu...

Arsenic is one of the heavy metals and nearly all its compounds, especially organic compounds, are toxic. The wide spectrum of diseases caused by this element has led to evaluation of the toxicity of different arsenic species and identification of the major natural and anthropogenic pollution sources of it in the nature. Mining activities are among the main sources of anthropogenic pollution of...

Arsenic is a well-known human carcinogen. Stem cells are indicated to be involved in arsenic carcinogenesis and have a survival selection advantage during arsenic exposure with underlying mechanisms undefined. In the present study, we demonstrated that CD34high-enriched cells derived from HaCaT human keratinocytes showed stem-like phenotypes. These cells were more resistant to arsenic toxicity ...

Arsenic is a ubiquitous trace element that has been shown to induce both systemic and carcinogenic effects. Epidemiological findings show that exposure to arsenic results in cardiovascular, gastrointestinal, and neurological disorders, as well as, various neoplastic diseases, such as, skin, lung, bladder, liver and kidney cancers. Although the mechanism of arsenic toxicity is not fully understo...

Arsenic is a toxic metalloid that exists ubiquitously in the environment, and affects global health problems due to its carcinogenicity. In most populations, the main source of arsenic exposure is the drinking water. In drinking water, chronic exposure to arsenic is associated with increased risks of various cancers including those of skin, lung, bladder, and liver, as well as numerous other no...

Underground water in many regions of the world is contaminated with high concentrations of arsenic and the resulting toxicity has created a major environmental and public health problem in the affected regions. Chronic arsenic exposure can cause many diseases, including various physical and psychological harms. Although the physical problems caused by arsenic toxicity are well reported in liter...