نتایج جستجو برای: arsb gene

تعداد نتایج: 1141400  

Objective(s): Mucopolysaccharidosis VI (MPS VI) or Maroteaux-Lamy syndrome is a rare metabolic disorder, resulting from the deficient activity of the lysosomal enzyme arylsulfatase B (ARSB).  The enzymatic defect of ARSB leads to progressive lysosomal storage disorder and accumulation of glycosaminoglycan (GAG) dermatan sulfate (DS), which causes harmful effects on various organs and tissues an...

Journal: :The Journal of biological chemistry 1992
D Dou J B Owolabi S Dey B P Rosen

Resistance to toxic oxyanions of arsenic and antimony in Escherichia coli is conferred by the conjugative R-factor R773, which encodes an ATP-driven anion extrusion pump. The ars operon is composed of three structural genes, arsA, arsB, and arsC. Although transcribed as a single unit, the three genes are differentially expressed as a result of translational differences, such that the ArsA and A...

2013
Zhangqi Shen Jing Han Yang Wang Orhan Sahin Qijing Zhang

Arsenic, a toxic metalloid, exists in the natural environment and its organic form is approved for use as a feed additive for animal production. As a major foodborne pathogen of animal origin, Campylobacter is exposed to arsenic selection pressure in the food animal production environments. Previous studies showed that Campylobacter isolates from poultry were highly resistant to arsenic compoun...

2016
Roger S Holmes

Multiple sulfatase genes have been reported on the human genome, including Arylsulfatase B (ARSB), Arylsulfatase I (ARSI) and Arylsulfatase J (ARSJ). ARSB is localized in lysosomes and catalyses the hydrolysis of chondroitin and dermatan sulfate groups. Bioinformatic analyses of vertebrate genomes were undertaken using known human ARSB, ARSI and ARSJ amino acid sequences to study the relatednes...

2015
Tânia Sousa Rita Branco Ana Paula Piedade Paula V. Morais Alexandre Poulain

Ochrobactrum tritici SCII24T is a highly As-resistant bacterium, with two previously described arsenic resistance operons, ars1 and ars2. Among a large number of genes, these operons contain the arsB and Acr3 genes that encode the arsenite efflux pumps responsible for arsenic resistance. Exploring the genome of O. tritici SCII24T, an additional putative operon (ars3) was identified and revealed...

2015
Anusha Uttarilli Prajnya Ranganath S. Jamal Md Nurul Jain Prasad C. Krishna Anupam Sinha Ishwar C. Verma Shubha R. Phadke Ratna D. Puri Sumita Danda Mamta N. Muranjan Ganesh Jevalikar H. A. Nagarajaram Ashwin B. Dalal

BACKGROUND & OBJECTIVES Mucopolysaccharidosis type VI (MPS VI) is a rare, autosomal recessive lysosomal storage disorder caused by deficient enzymatic activity of N-acetyl galactosamine-4-sulphatase resulting from mutations in the arylsulphatase B (ARSB) gene. The ARSB gene is located on chromosome 5q11-q13 and is composed of eight exons. More than hundred ARSB mutations have been reported so f...

2015
Rita Ferla Pamela Claudiani Marco Savarese Karen Kozarsky Rossella Parini Maurizio Scarpa Maria Alice Donati Giovanni Sorge John J. Hopwood Giancarlo Parenti Simona Fecarotta Vincenzo Nigro Hatice Serap Sivri Ans Van Der Ploeg Generoso Andria Nicola Brunetti-Pierri Alberto Auricchio

Recombinant vectors based on adeno-associated virus serotype 8 (AAV8) have been successfully used in the clinic and hold great promise for liver-directed gene therapy. Preexisting immunity against AAV8 or the development of antibodies against the therapeutic transgene product might negatively affect the outcomes of gene therapy. In the prospect of an AAV8-mediated, liver-directed gene therapy c...

2014
Paola Saccone Gabriella Cotugno Fabio Russo Rosa Mastrogiacomo Alessandra Tessitore Alberto Auricchio Elvira De Leonibus

Maroteaux-Lamy disease, also known as mucopolysaccharidosis (MPS) VI, is an MPS disorder caused by mutations in the ARSB gene encoding for the lysosomal enzyme arysulfatase B (ARSB). Deficient ARSB activity leads to lysosomal accumulation of dermatan sulfate in a wide range of tissues and organs. There are various animal models of MPS VI that have been well characterized from a biochemical and ...

Journal: :Applied and environmental microbiology 2006
Lianrong Wang Shi Chen Xiang Xiao Xi Huang Delin You Xiufen Zhou Zixin Deng

In the arsenic resistance gene cluster from the large linear plasmid pHZ227, two novel genes, arsO (for a putative flavin-binding monooxygenase) and arsT (for a putative thioredoxin reductase), were coactivated and cotranscribed with arsR1-arsB and arsC, respectively. Deletion of the ars gene cluster on pHZ227 in Streptomyces sp. strain FR-008 resulted in sensitivity to arsenic, and heterologou...

2012
Sumit Bhattacharyya Joanne K. Tobacman

This report presents evidence of 1) a role for arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) in mediating intracellular oxygen signaling; 2) replication between the effects of ARSB silencing and hypoxia on sulfated glycosaminoglycan content, cellular redox status, and expression of hypoxia-associated genes; and 3) a mechanism whereby changes in chondroitin-4-sulfation that follow ei...

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