atrial fibrillation (af) is a commonly encountered arrhythmia in our daily practice. every year a huge bulk of data is published about different management strategies, new antiarrhythmic drugs, anticoagulation protocols and ablation procedures in these patients. in this review article, we discuss different management strategies and new antiarrhythmic drugs as well as those commonly used. we wil...

introduction:  treatment of rapid ventricular response arterial fibrillation (rapid af) varies depending on the decision of the in-charge physician, condition of the patient, availability of the drug, and the treatment protocol of the hospital. the present study was designed aiming to compare iv digoxin and amiodarone in controlling the heart rate of patients presenting to emergency department ...

Many kinase inhibitors, chemotherapeutic agents, antiemetics, antibiotics, and antifungal agents can prolong QT intervals, placing the patient as risk for the life-threatening ventricular arrhythmia Torsade de pointes (Tdp). In addition, common electrolyte imbalances experienced by many patients with cancer compound the risk. Because numerous medications used in oncology and common electrolyte ...

The understanding of the mechanisms of action and side effects of different antiarrhythmic drugs (AAD) are essential for their appropriate use. With the advent of effective and safe ablation therapy, AAD therapy has undergone dramatic changes. This review attempts to understand the rationale behind the clinical use of medical management of different arrhythmias.

7-{2-Hydroxy-3-[4-(2-phenoxyethyl)-piperazinyl-1-yl]-propyl}-1,3-di-methyl-3,7-dihydro-1H-purine-2,6-dione dihydrochloride (2), and several of its 8-alkylamino substituted derivatives (11-17) were synthesized and tested for electrocardiographic, antiarrhythmic and hypotensive activity. Also their alpha(1)- and alpha(2)-adrenoreceptor affinities were determined. It was found that compound 2, and...

上室性,心室性期外収縮,心房細動,心房粗動など 日常臨床で遭遇する頻脈性不整脈に対して,治療を目 的としてさまざまな抗不整脈薬が用いられる.しかし これまでは,実際の薬剤選択に適用可能なプラクティ カルなガイドラインはほとんど示されておらず,各担 当医の知識と経験に負うところが大きかった.特に近年 新しい強力な抗不整脈薬が次々と開発され,数多くの 薬剤を臨床で用いることができるようになってからは, それまで治療に抵抗していた不整脈がコントロール 可能になった反面,個々の症例に対してこれらの薬 剤をどのように選択し,使い分けて行くかが実際上大 きな問題になってきた.さらに最近では薬物療法のみ ならず,カテーテルアブレーションや植え込み型除細 動器などの非薬物療法の進歩も著しく,治療現場にお ける選択肢がますます広がっている点も考慮しなけれ ばならない. 一方,近年欧米で行われた抗不整脈...

A severe case of flecainide-induced incessant ventricular arrhythmias is presented. These arrhythmias were resistant to various intravenous antiarrhythmic drugs and to cardiac pacing. Intravenous amiodarone administered over a short period and in a high dose strikingly abolished all ventricular arrhythmias.