rosmarinus officinalis l., a medicinal herb from the labiates family, has been reported to be of potential benefit in the treatment and prevention of several diseases. in particular its phenolics have demonstrated protective effects on various types of cancer through several mechanisms. the present study aimed to determine the effects of rosemary phenolic extracts on human cell functions, with ...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 one of the prominent types of connective tissue cells is fibroblast that synthesizes and maintains the extracellular matrix of many animal tissues. previous studies illustrated that calprotectin protein has different cytotoxicity effects on fibroblast cells. calprotectin is abundant in the neutrophil cytosol; it has growth...

objective(s):fumonisins are a group of toxic and carcinogenic mycotoxins, which contaminate the grains and their products. the aim of this study was to examine the apoptotic and proliferative activity of mouse gastric mucosa following administration of fumonisin b1 (fb1).    materials and methods: twenty-nine female mice divided into treatment (n=15) and control (n=14) groups. the treatment gro...

background micrornas are small and non-coding rna molecules with approximately 22 nt in length that cause inhibition of translation or degradation of mrna. mir-155 is a kind of molecule with different functions, such as its role in proliferation, apoptosis, inflammation, differentiation, and immunity. one of its best known functions is apoptosis that affects on caspase-3 activity. the main aim ...

objective(s): the role of aluminum (al) in the pathogenesis of neurodegenerative diseases has been implicated in several studies. however, the exact mechanisms of cytotoxic effects of al have not been elucidated yet. the aim of this study was to investigate the effect of l-type calcium channel antagonist, nimodipine (nm), and lithium chloride (licl) on al-induced toxicity in pc12 cells. materia...

abstractferulago angulata boiss. known in iran as chavir, has some bioactive compounds having antioxidant activity. because of its antioxidant activities, it sounded chavir extract can be a good candidate for finding chemopreventive agents having inductive apoptosis properties on cancer cells. in this study, the cytotoxic effects and proapoptotic activities of chavir’s leaf and flower extracts ...

objective(s):valproic acid (vpa), a drug used in the treatment of neurological disorders, has been shown to have cytotoxic effects on cancer cells through different mechanisms. telomerase, a ribonucleoprotein reverse transcriptase, is responsible for elongation of the telomere and is activated in cancers. a relation between telomerase activity and resistance to apoptosis has been established. t...

introduction: evidence suggests that neuronal apoptosis in neurodegenerative diseases is correlated with inflammatory reactions. the beneficial or detrimental role of apoptosis in neuroinflammation is unclear. elucidating this question may be helpful in management of neurodegenerative diseases. since tnf-α is able to induce apoptosis as well as increased viability of the cells by activation of ...

abstractthe purpose of this investigation was to evaluate the antiproliferative and apoptogenic mechanistic studies of methanol extract of anthocephalus cadamba (meac) on dalton’s lymphoma ascites (dla) cells treated mice. determination of antiproliferative activity was performed by using different dla cells (2×106 cells, i.p.) inoculated mice groups (n=12). groups were treated for 14 consecuti...