BACKGROUND Relapsed childhood acute myeloid leukemia (AML) outcomes have not been documented in resource-limited settings. We examined survival after relapse for children with AML (non-APML) and acute promyelocytic leukemia (APML) in Central America. PROCEDURE We retrospectively evaluated outcomes of children with first relapse of AML (non-APML) and APML in Guatemala, Honduras, or El Salvador...

Acute Promyelocytic Leukaemi.a (APML) is an uncommon type of acute non-lymphocytic leukaemia (ANLL)l. Treatment of APML is associated with significant mortality and morbidity. Ten to twenty per cent of the patients die early of fatal haemorrhage resulting from coagulopathy and sepsis. An alternative approach to the treatment of APML has centered on the use of differentiating agents to induce re...

We describe a method of synthesising contextually appropriate intonation with limited domain unit selection voices. The method enables the natural language generation component of a dialogue system to specify its intonation choices via APML, an XML-based markup language. In a pilot study, we built an APML-aware limited domain voice for use in flight information dialogues, and carried out a perc...

Autofluorescence is an immunophenotypic characteristic of leukemic blasts in acute promyelocytic leukemia (APL). We examined the fluorescent intensity of isotype controls in 25 cases of APML and 25 controls with acute myeloid leukemia. The fluorescence of the FITC- and PE-conjugated controls was consistently higher in APML. Autofluorescence may therefore represent a helpful diagnostic marker in...

Acute promyelocytic leukaemia (APML) is a subtype of leukaemia arising from a distinct reciprocal translocation involving chromosomes 15 and 17, which results in the PML-RARA fusion gene. Over the past three decades, APML has been transformed from a highly fatal disease to a highly curable one. This drastic improvement is because of the introduction of a new treatment strategy with all-trans re...

OBJECTIVES Surface CD56 expression on leukemic cells in acute promyelocytic leukemia (APML) is considered an indicator of poorer outcome even in patients receiving conventional treatment. METHODS In the present case, at initial diagnosis, the hallmark phenotype of APML was found (strong CD33 and cytoplasmic MPO expression, absence of HLA-DR expression). RESULTS Both CD34 and CD56 antigen ex...

Treatment related acute myeloid leukemia (t-AML) is well documented phenomenon after chemotherapy. In this subgroup of patients acute promyelocytic leukemia (APML) due to delayed complication of using anthracycline is very rare occurrence. Very few cases are reported in world literature. We are reporting a rare case of occurrence of t-APML in cured breast cancer patient treated with doxorubicin...

Acute promyelocytic leukaemia (APML) is characterised by the t(15;17)(q22;q21), that results in the fusion of the promyelocytic leukaemia (PML) gene at 15q22 with the retinoic acid α-receptor (RARA) gene at 17q21. The current case report describes a 13-year-old male with APML, who was negative for PML/RARA fusion signal but reported to have an atypical translocation t(16;17). To the best of our...

A 45-year-old woman presented with sudden severe excruciating headache. Medical history disclosed intermittent fever and weight loss in the past 3 months. No focal neurological deficits were seen. CT scan disclosed diffuse subarachnoid hemorrhage. Cranial CT angiography showed no intracranial aneurysms (Figure). Laboratory evaluation disclosed thrombocytopenia, anemia and abnormalities of white...

Este trabajo es una aportación a la escasa historiografía sobre el asociacionismo profesional médico en España primera mitad del siglo XX. La Agrupación Profesional de Médicos Liberales (APML), creada durante II República Española, no sólo intentó romper con los antecedentes asociativos tradicionales profesión médica, sino que participó activamente nivel político y social objetivo obtener medic...