BACKGROUND The aim of the study was to explore the mechanisms underlying the association of birth weight with later body mass index (BMI) from the biochemical markers related to metabolism and the Apa I polymorphism in IGF-II gene. METHODS A total of 300 children were selected randomly from the Macrosomia Birth Cohort in Wuxi, China. The height and weight were measured and blood samples were ...

Objective Genetic and environmental factors are important in the development of the multiple sclerosis (MS). Vitamin D shows its effects on the immune system with the vitamin D receptor (VDR) in the nucleus. Single nucleotide polymorphisms (SNPs) in the VDR gene can lead to alterations in vitamin D functions and metabolism.Taq I, Apa I, Fok I and Bsm I polymorphisms and MS associations have bee...

the aim of the study was to explore the mechanisms underlying the association of birth weight with later body mass index (bmi) from the biochemical markers related to metabolism and the apa i polymorphism in igf-ii gene.a total of 300 children were selected randomly from the macrosomia birth cohort in wuxi, china. the height and weight were measured and blood samples were collected. plasma conc...

Background Single-nucleotide polymorphism within the gene encoding Vitamin D receptor (VDR) – a member of the nuclear receptor supergene family, is associated with several infectious diseases. The receptor belongs to the family of trans-acting transcriptional regulatory factors. Studies on VDR gene polymorphism reveals Fok I, Taq I, & Apa I restriction site variants to be significantly associat...

Purpose Dental caries is a multifactorial infectious disease. In this study, we investigated whether single nucleotide polymorphisms (SNPs) in vitamin D receptor (VDR) gene were associated with susceptibility to permanent tooth caries in Chinese adolescents. Method A total of 200 dental caries patients and 200 healthy controls aged 12 years were genotyped for VDR gene polymorphisms using the ...

BACKGROUND Autism spectrum disorder (ASD) is a group of heterogeneous, behaviorally defined disorders whereby currently no biological markers are common to all affected individuals. A deregulated immune response may be contributing to the etiology of ASD. The active metabolite of vitamin D₃ has an immunoregulatory role mediated by binding to the vitamin D receptor (VDR) in monocyte, macrophages...

BACKGROUND The aim is to define the role of single nucleotide polymorphism on the progress of hepatitis B virus (HBV) infection. We evaluated polymorphisms of TNF-α-308, Vitamin D receptor Apa I and Taq I gene in patients with HBV infection. METHODS All subjects included were older than 18 years old. Sixty three patients had chronic HBV infection, 61 were HBsAg positive carriers and 59 were p...