abstractthe purpose of this investigation was to evaluate the antiproliferative and apoptogenic mechanistic studies of methanol extract of anthocephalus cadamba (meac) on dalton’s lymphoma ascites (dla) cells treated mice. determination of antiproliferative activity was performed by using different dla cells (2×106 cells, i.p.) inoculated mice groups (n=12). groups were treated for 14 consecuti...

in view of potential biological activities of small molecule polyamides, we synthesized some novel n-(2-aminoethyl)-1-benzyl-2- (alkylthio)-1h-imidazole-5-carboxamide (7a,b), and n-(2-(1-benzyl-2-(alkylthio) -1h-imidazole- 5-carboxamido) ethyl)-1-benzyl-2- (alkylthio)-1h-imidazole-5-carboxamides (8a,b) as antitumor agents. the antitumor activity of compounds 7a,b and 8a,b was studied at concent...

objective: methanol extract of bran and unpolished grain of two traditional aromatic rice genotypes viz. kalijira and chinigura were assayed for their activity on the growth and initiation of crown-gall tumors on potato disks. materials and methods: three agrobacterium tumefaciens (a. tumefaciens) strain atsl0105, atta0112, and atac0114 were used as the tumor forming agent. collected rice was s...

this work was to isolate and identify the bioactive secondary metabolite which was produced by myxobacterium stigmatella eracta wxnxj-b, and to evaluate its antitumor and apoptosis-inducing effects. the results showed that one novel compound (molecular formula c29h25no3) was isolated, purified by sephadex lh-20 column chromatography and preparative rp-hplc, and identified as 5-(6-benzyl-quinoli...

different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3, 1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g., hydrazine hydrate, and formamide. some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against...

ft-sers (fourier transform surface enhanced raman scattering) of adriamycin and its complex with dna is reported. it is shown that in agreement with previous raman studies the interaction of adriamycin  with dna takes place through an intercalation mechanism. the presence of a new band at 731 cm-1 suggests that ring d of adriamycin is not involved in the intercalation process.

Epithelial Ovarian cancer is the leading cause of cancer mortality among women all over the world. As chemotherapeutics has many side effects, researchers have focused on the potential use of medicinal plants as natural antitumor agents. Xanthium strumarium studied in this work as an herbal anticancer agent. This study aimed to evaluate the antitumor effect and metabolic alterations ca...

Antitumor Agents. In their Research Article (e202303958), Pritha Ray, Malay Patra et al. report the design and synthesis of an in vivo potent, kinetically inert platinum organometallic antitumor agent.

paris polyphylla smith var. yunnanensis, has been used in traditional chinese medicine for its antibiotic and anti-inflammatory properties; in addition it has been used to cure liver cancer in particular. in this current study, β-ecdysterone (1) and three pennogenin steroidal saponins (2-4) were isolated from the etoh extract of paris polyphylla var. yunnanensis, and then tested for their antit...