introduction thyroid storm is a rare complication of graves' disease that can carry a poor prognosis. in order to prevent major complications, thyroid storm must be quickly identified in patients and treatment must be promptly implemented. medical treatment is usually initiated with antithyroid medications, such as propylthiouracil (ptu), methimazole, and beta-blockers. however, some patients m...

Methimazole and propylthiouracil have been used in the management of hyperthyroidism for more than half a century. However, hepatotoxicity is one of the most deleterious side effects associated with these medications. The mechanism(s) of hepatic injury induced by antithyroid agents is not fully recognized yet. Furthermore, there are no specific tools for predicting the occurrence of hepatotoxic...

Drug-induced liver injury (DILI) is a major problem for pharmaceutical industry and drug development. Mechanisms of DILI are many and varied. Elucidating the mechanisms of DILI will allow clinicians to prevent liver failure, need for liver transplantation, and death induced by drugs. Methimazole and propylthiouracil (PTU) are two convenient antithyroid agents which their administration is accom...

Considering the therapeutic aspects of thyrotoxicosis, 980 cases were studied, where probable role of stress in the etiopathogenesis has been explored. These cases were then treated with standard modern therapy containing antithyroid drug with a tranquilizer and some of the patients were treated only by an Ayurvedic drug. i. e. Sankhapuspi. In early cases Sankhapuspi was found more effective th...

Despite 70 years of experience treating thyrotoxic patients with radioiodine not all patients are successfully treated by a single dose. Multiple factors predicting radioiodine efficacy have been reported. The aim of this study was to assess whether ethnicity was associated with radioiodine response. A retrospective review was performed of patients who received radioiodine therapy for thyrotoxi...

Graves' disease (GD) accounts for 10%-15% of thyroid disorders in children and adolescents. The use of antithyroid drugs as the initial treatment option in GD is well accepted. An average two years remission is achieved in about 30% of children treated with antithyroid drugs. However, the optimal treatment duration and the predictive marker of remission after antithyroid drug therapy are still ...