Neutralization of streptokinase by an unsuspected high titer of antistreptokinase antibody prevented activation of the fibrinolytic system and induction of a lytic state in a 62 year old man with an acute inferior myocardial infarction. There was no decrease in serum fibrinogen, minimal decrease in serum plasminogen and only a small increase in serum fibrin degradation products after intravenou...

Streptokinase activates platelets, limiting its effectiveness as a thrombolytic agent. The role of antistreptokinase antibodies and proteases in streptokinase-induced platelet activation was investigated. Streptokinase induced localization of human IgG to the platelet surface, platelet aggregation, and thromboxane A(2) production. These effects were inhibited by a monoclonal antibody to the pla...

Accepted for publication 13 January 1992 Abstract Objective-To examine the induction of antistreptokinase antibodies after giving streptokinase or anistreplase to patients with acute myocardial infarction. Design-Patients were randomly allocated to receive either 15 x 10' IU, streptokinase or 30U anistreplase in a double blind study. Blood samples were collected immediately before treatment and...

Streptokinase activates platelets, limiting its effectiveness as a thrombolytic agent. The role of antistreptokinase antibodies and proteases in streptokinase-induced platelet activation was investigated. Streptokinase induced localization of human IgG to the platelet surface, platelet aggregation, and thromboxane A2 production. These effects were inhibited by a monoclonal antibody to the plate...

given over 30-60 minutes. The patency of infarct-related artery (IRA) is approximately 50-60% while the rate of reocclusion is approximately 5-20%.2,3 Rheumatic fever and streptococcal infection are still prevalent in developing countries, which results in high antistreptokinase (ASK) titer in patients who sustained a previous streptococcal Ahmed M. Abuosa, MD, MRCP, Fawaz Akhras, FRCP, Khaled ...

There are two groups in the inhibitors of fibrinolytic enzyme system : antiplasmins, the direct inhibitors of the enzyme ; and the inhibitors of activators, such as the antistreptokinase, the antiurokinase and the inhibitors of tissue kinases. Moreover, several synthetic compounds such as EACA and AMCHA are also capable of inhibiting fibrinolysis.1) Since the nature of the inhibitors and the me...

the measurement of anti-streptokinase antibodies can distinguish the patients who may benefit from streptokinase and those who should be treated with some other thrombolytic regimen. neutralising titration test is a commonly used classical assay for measuring anti-streptokinase antibodies and in this assay the ability of anti-streptokinase antibodies in patients' sera in preventing the lytic ef...