sudden, unexpected death may occur in apparently healthy individuals. its occurrence in psychiatric patients has raised the concern that the use of psychotropics, especially antipsychotics, may be associated with an increased risk of sudden death. this concern is maintained even though not all psychiatric patients who have succumbed to sudden death have been on psychotropics. early reports pres...

The term psychosis refers to a variety of mental disorders characterized by one or more of the following symptoms: diminished and distorted capacity to process information and draw logical conclusions, hallucinations, delusions, incoherence or marked loosening of associations, catatonic or disorganized behavior, and aggression or violence. Antipsychotic drugs lessen these symptoms regardless of...

in this study, the aim was to determine whether adding vitamin d to the standard therapeutic regimen of schizophrenic male patients with inadequate vitamin d status could improve some aspects of the symptom burden or not. this study was an open parallel label randomized clinical trial. eighty patients with chronic stable schizophrenia with residual symptoms and vitamin d deficiency were recruit...

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 837 1. Early Stages of Schizophrenia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 839 2. Efficacy of Antipsychotic Drugs in First-Episode Schizophrenia . . . . . ...

Priapism is a rare but important side effect of antipsychotic drugs which may evolve into a urological emergency. Most antipsychotic drugs are alpha-1 adrenergic antagonists, which is thought to be the principal mechanism involved in antipsychotic-induced priapism. Other aetiologies exist, however. A case is presented with multiple episodes of priapism during the use of several different antips...

objective: the present study aimed to review the relapse rate in patients with schizophrenia treated with orally taken atypical agents (serotonin dopamine antagonists, sdas) and depot preparation of conventional (typical) antipsychotics. methods: in this historical cohort study, mean relapse per month (mrm) index, duration between initiation of antipsychotic treatment and the first relapse epis...

Atypical antipsychotic drugs, which are distinguished from typical antipsychotic drugs by a lower incidence of extra-pyramidal side effects and less propensity to elevate serum prolactin levels (e.g., clozapine, olanzapine, risperidone, quetiapine, ziprasidone), have become the most widely used treatments for schizophrenia, although their precise mechanism of action remains controversial. It ha...