In this paper we focus our attention on the role of two families of receptors, Toll-like receptors (TLR) and decoy receptors (DcR) involved in the generation of systemic lupus erythematosus (SLE) and lupus-like syndromes in human and mouse models. To date, these molecules were described in several autoimmune disorders such as rheumatoid arthritis, antiphospholipids syndrome, bowel inflammation,...

conclusions antipospholipid antibodies based on number of abortions and gestational age of abortions were increased. mean antipospholipid and anticardiolipin antibodies in all patients remained in high level just in first 5 years post abortion and then began to fall. results mean age of participants was 24-39 years old. the average rate of antiphospolipid antibodies in patients with normal anti...

adverse outcome of pregnancy is a potentially dangerous complication of conception and affects 15-20% of pregnancies. according to recent studies increased level of blood antiphospholipids antibodies, if accompanied by predisposing factors, can be an adverse event in human pregnancy. the aim of the present study was to compare the maternal serum levels of anticardiolipin and antiphosphatidyl se...

Adverse outcome of pregnancy is a potentially dangerous complication of conception and affects 15-20% of pregnancies. According to recent studies increased level of blood antiphospholipids antibodies, if accompanied by predisposing factors, can be an adverse event in human pregnancy. The aim of the present study was to compare the maternal serum levels of anticardiolipin and antiphosphatidyl se...

This report describes the onset of systemic capillary leak (SCL)-like syndrome in a 30-year-old woman with antiphospholipids syndrome (APS) during puerperium.Twelve hours after a cesarean section, she presented a sudden fever and abdominal pains followed by dyspnea, severe edema of the limbs and pelvis.Computer tomography shows congestion of interstitial pulmonary parenchyma, pericardial and pl...

Apoptotic cells are rapidly phagocytosed by professional phagocytes, such as macrophages and dendritic cells. This process prevents the release of potentially noxious or immunogenic intracellular materials from dying cells, and is thought to play a critical role for the maintenance of normal functions in surrounding tissues. Milk fat globule-EGF-factor 8 (MFG-E8), secreted by activated macropha...

OBJECTIVE To determine the risk of pre-eclampsia associated with factors that may be present at antenatal booking. DESIGN Systematic review of controlled studies published 1966-2002. DATA SYNTHESIS Unadjusted relative risks were calculated from published data. RESULTS Controlled cohort studies showed that the risk of pre-eclampsia is increased in women with a previous history of pre-eclam...