background : many studies have investigated the effects of psychological factors on disease activity in patients with ulcerative colitis (uc). however, the number of studies that have assessed the correlation between immunologic markers of uc and psychological distress are few. therefore, we designed a study to determine the association between two immuno-biological markers, peripheral/central ...

Methods We report the case of 8 year old boy who was referred to our hospital with 11 days history of high fever (39.5°C), fatigue, anorexia and weight loss. Two days prior to admission he began to complain of pain in the calves muscles, developed petechial skin rash and hematomas, gross haematuria and gastrointestinal (GI) bleeding. At admission was febrile, in very poor condition, hyperventil...

ANCA-associated vasculitis (AAV) is a rare and potentially life threatening complication associated with antithyroid drug use. It is more commonly reported with propylthiouracil, with fewer cases reported with methimazole use. We present the case of a 55-year-old man with toxic multinodular goiter which was treated with methimazole for 6 months. He developed ANCA positive leukocytoclastic vascu...

Septal perforation from intranasal cocaine abuse is well recognised. We present a case of progressive septal as well as palatal perforation. Progression from septal perforation to palatal perforation occurred after cessation of intranasal cocaine abuse. This patient had a weakly positive cytoplasmic antineutrophilic cytoplasmic antibody (C-ANCA) but no histologic evidence of Wegener's Granuloma...

Cocaine-associated retiform purpura is a recently described entity characterized by striking hemorrhagic necrosis involving areas of skin associated with administration of cocaine. Levamisole, an adulterant in cocaine, has been suggested as the main culprit pathogenetically. Four cases of cocaine-associated retiform purpura were encountered in the dermatopathology practice of C. M. Magro. The l...