نتایج جستجو برای: antimycobacterial activity

تعداد نتایج: 1135098  

Journal: :international journal of infection 0
javad abkhoo institute of plant biotechnology, university of zabol, zabol, ir iran somayeh jahani infectious diseases and tropical medicine research center, zahedan university of medical sciences, zahedan, ir iran; infectious diseases and tropical medicine research center, zahedan university of medical sciences, zahedan, ir iran. tel: +98-9155427940, fax: +98-5433229792 mahdieh shafaghat infectious diseases and tropical medicine research center, zahedan university of medical sciences, zahedan, ir iran

results results of the current study showed that the minimum inhibitory concentration value of cinnamaldehyde against m. tuberculosis was 200 µg/ml. moreover, rt-pcr data showed that a total of 25 genes were regulated by the cinnamaldehyde. of these, 12 genes were up-regulated, and 13 genes were down-regulated. conclusions cinnamaldehyde is a pattern to expand the new anti-tb drugs, because the...

Journal: :the iranian journal of pharmaceutical research 0
barbaros eroglu hacettepe university, faculty of pharmacy, department of pharmaceutical chemistry ozadali sari keriman hacettepe university, faculty of pharmacy, department of pharmaceutical chemistry oya unsal tan hacettepe university, faculty of pharmacy, department of pharmaceutical chemistry sriram dharmarajan medicinal chemistry & antimycobacterial research laboratory, pharmacy group, birla institute of technology & science perumal yogeeswari medicinal chemistry & antimycobacterial research laboratory, pharmacy group, birla institute of technology & science ayla balkan department of pharmaceutical chemistry, faculty of pharmacy, hacettepe university

to develop novel antimycobacterial agents, a new series of thiazolidinone-azole hybrids 4a-b, 5a-b and 6-13 were designed and synthesized. thiazolidin-4-ones (4a-b and 5a-b) were obtained by the reaction of schiff bases and hydrazones (2a-b and 3a-b) with mercaptoacetic acid. 5-benzylidene derivatives (6-13) were gained by treatment of 5a-b with appropriate benzaldehydes according to knoevenage...

Abbas Shafiee, Ali Almasirad, Somayeh Samiee-Sadr

A series of new 2-(phenylthio) benzoylaryl hydrazones were synthesized by acid-catalyzed condensation of hydrazide 3 with corresponding aldehydes. The chemical structures of the compounds were elucidated by FT-IR, 1H-NMR and Mass spectra. All newly synthesized compounds were evaluated for their antimycobacterial activities against Mycobacterium tuberculosis H37Rv using the microplate alamar blu...

To develop novel antimycobacterial agents, a new series of thiazolidinone-azole hybrids 4a-b, 5a-b and 6-13 were designed and synthesized. Thiazolidin-4-ones (4a-b and 5a-b) were obtained by the reaction of Schiff bases and hydrazones (2a-b and 3a-b) with mercaptoacetic acid. 5-Benzylidene derivatives (6-13) were gained by treatment of 5a-b with appropriate benzaldehydes according to Knoevenage...

Journal: :Pharmaceutical Biology 2007

Journal: :Journal of applied biology and biotechnology 2023

Antimycobacterial and antibiofilm activity of garlic essential oil using vapor phase techniquesAshirbad Sarangi, Bhabani Shankar Das, Sunil Swick Rout, Ambika Sahoo, Sidhartha Giri, Debapriya Bhattacharya

To develop novel antimycobacterial agents, a new series of thiazolidinone-azole hybrids 4a-b, 5a-b and 6-13 were designed and synthesized. Thiazolidin-4-ones (4a-b and 5a-b) were obtained by the reaction of Schiff bases and hydrazones (2a-b and 3a-b) with mercaptoacetic acid. 5-Benzylidene derivatives (6-13) were gained by treatment of 5a-b with appropriate benzaldehydes according to Knoevenage...

Journal: :iranian journal of pharmaceutical research 0
ali almasirad department of medicinal chemistry, facalty of pharmacy, pharmaceutical sciences branch, islamic azad university, tehran, iran. somayeh samiee-sadr department of medicinal chemistry, facalty of pharmacy, pharmaceutical sciences branch, islamic azad university, tehran, iran. abbas shafiee department of medicinal chemistry, faculty of pharmacy and pharmaceutical sciences research center, tehran, iran.

a series of new 2-(phenylthio) benzoylaryl hydrazones were synthesized by acid-catalyzed condensation of hydrazide 3 with corresponding aldehydes. the chemical structures of the compounds were elucidated by ft-ir, 1h-nmr and mass spectra. all newly synthesized compounds were evaluated for their antimycobacterial activities against mycobacterium tuberculosis h37rv using the microplate alamar blu...

Journal: :Frontiers in Microbiology 2021

Drug-resistant tuberculosis threatens to undermine global control programs by limiting treatment options. New antimicrobial drugs are required, derived from new chemical classes. Natural products offer extensive diversity and inspiration for synthetic chemistry. Here, we isolate, synthesize test a library of 52 natural compounds activity against Mycobacterium . We identify seven as antimycobact...

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