As antibiotic resistance increases worldwide, there is an increasing pressure to develop novel classes of antimicrobial compounds to fight infectious disease. Peptide therapeutics represent a novel class of therapeutic agents. Some, such as cationic antimicrobial peptides and peptidoglycan recognition proteins, have been identified from studies of innate immune effector mechanisms, while others...

The purpose of this manuscript is to summarise current issues in antimicrobial therapeutics, specifically relating to antibacterial drugs, in the critical care setting. Antimicrobial taxonomy, mode of action, pharmacokinetics and pharmacodynamics are important considerations in choosing the most appropriate agent for treatment of infections. Adverse effects of antibiotics can range from mild ga...

background and objectives: there is increasing emergence of multidrug resistant pseudomonas aeruginosa (mdrpa) strains and drug resistance is positively-correlated with biofilm-forming ability. since about 10% of p. aeruginosa genome is controlled by quorum sensing (qs), alteration in its antibiotic susceptibility by targeting qs was the focus of the present study. materials and methods : one d...

The search for novel antimicrobial agents to combat microbial pathogens is intensifying in response rapid drug resistance development current antibiotic therapeutics.