The role of macrophages in hepatic amoebiasis in hamsters has been investigated by means of antimacrophage serum prepared in rabbits. Animals treated with normal rabbit serum or antimacrophage serum, as well as untreated controls, were inoculated intrahepatically with 10(5) axenic trophozoites of Entamoeba histolytica. In hamsters treated with antimacrophage serum before intrahepatic inoculatio...

the immunosuppressive effect of antimacrophage serum (ams) on the primary immune response of mice to sheep red blood cells (srbc) was studied. ams, given before a small dose of antigen, abrogated the immune response. transplantation of normal, galss-adherent macrophages enabled ams-treated animals to respond to srbc, while administration of lymph node lymphocytes did not reveres ams - induced i...

Ten primary 3-methylcholanthrene-induced murine sarco mas ranging in size from 0.37 to 3.22 ml were selected for studies of tumor-associated immunoglobulin. The purpose of these particular studies was to determine if a significant pro portion of the immunoglobulin was bound to receptors for the Fc portion of Immunoglobulin G molecules on tumor-associated host lymphoreticular cells. The distribu...

Ten primary 3-methylcholanthrene-induced murine sarco mas ranging in size from 0.37 to 3.22 ml were selected for studies of tumor-associated immunoglobulin. The purpose of these particular studies was to determine if a significant pro portion of the immunoglobulin was bound to receptors for the Fc portion of Immunoglobulin G molecules on tumor-associated host lymphoreticular cells. The distribu...

We have examined the roles of Fc receptors and complement receptors in mediating the interaction of sensitized sheep erythrocytes (E) with activated and with nonactivated mouse peritoneal macrophages. Both activated and nonactivated macrophages ingest IgG-coated erythrocytes [E(IgG)]; activated cells intest 1.5-2 times as man E(IgG) as do nonactivated macrophages. Thus, there is a quantitative ...

12-O-Tetradecanoylphorbol-13-acetate (TPA) added together with mitogenic lectins to bovine lymph node lymphocytes causes a synergistic increase in DNA synthesis. This comitogen effect is due to an increase in cell proliferation. To determine the role of macrophages in comitogenesis, lymphocyte preparations were depleted of macrophages by sequential adherence to glass, plastic, and nylon wool. P...

Partial immunity to schistosomiasis mansoni has been demonstrated in mice and has recently been transferred passively with serum, but not with cells. In vitro studies using human and rodent materials have demonstrated antibody-dependent cell-mediated damage to immature schistosomes (schistosomula); the cell involved in some of these in vitro systems appears to be the neutrophil and in others th...

Carrageenan potentiated in vivo the primary and secondary responses by concanavalin A (Con A)-bound L1210 murine leukemia vaccine and induced in histocompatible animals enhanced immune resistance to subsequent inoculations of live L1210 cells. This enhancement was critically dependent on the vaccine preparation and the administration timing of carrageenan. Carrageenan potentiated Con A-free vac...

Recent work demonstrated that a mannose receptor is involved in the phagocytosis of rod outer segments by the rat retinal pigment epithelium (RPE). In this study the binding of soluble mannose-containing ligands by human RPE explants is described. In addition, the authors report the isolation of a mannose receptor from human RPE and describe its relationship to the macrophage mannose receptor. ...