First-generation antihistamines can have adverse effects on the central nervous system and thereby complicate discharge planning from the emergency department (ED). Newer antihistamines are potentially safer, causing less sedation with similar efficacy. The aim of this study was to review the literature to better define which antihistamines are good options for the treatment of acute allergic r...

Background: It has been estimated that seasonal allergies affect up to approximately 44% of the population. Many people compromise the quality of their lives in order to function on a day to day basis. There are several treatments that are available in alleviating symptoms related to seasonal allergies, but many people have difficulty adhering to certain recommended regimens. Intranasal cortico...

limited evidence has been obtained concerning the beneficial effects of autologous serum therapy in treatment of skin disorders particularly chronic urticaria. in the present study, we have assessed the effect of this treatment method in patients with chronic urticaria (cu). this randomized single-blind controlled trial was performed on fifty consecutive patients with chronic urticaria. the pat...

Antihistamines are H1-receptor antagonists widely used in human and veterinary medicine to provide symptomatic relief of allergic signs caused by histamine release, including pruritus and anaphylactic reactions. Antihistamines are also commonly used as sedatives and antiemetics. 1 Antihistamines can be divided into first and second-generation (also called nonsedating) agents (Table 1). First-ge...

BACKGROUND H1 antihistamines are widely used as therapeutics for allergic diseases. Sedation is a well-known side effect of H1 antihistamines and sometimes it is life-threatening for patients. Thus it is important to evaluate the sedative properties of H1 antihistamines to avoid side effects. For this purpose, histamine H1 receptor (H1R) occupancy and proportional impairment ratios (PIR) are no...

There have been some recent studies on the clinical uses of the antihistamines as local anesthetic agents (1, 2, 3, 4). These have included the use of the antihistamines as local anesthetics for minor surgical procedures, nerve blocks and spinal anesthesia. The authors have compared the particular antihistamines under evaluation to procaine and, in general, have obtained results superior to tho...