antigenicity of proteins found in cow's milk is age dependent. this is primarily due to infants possessing a more permeable intestinal wall than that in adults. thus infants may acquire cow's milk allergy during their first year of life. while milk antigen specific ige may cause allergy in susceptible subjects, there is some evidence indicating that milk antigen specific igg may play some role ...

The enzyme d-ribonuclease is antigenic. Antisera, prepared by three different methods, reacted against antigen dilutions up to one million. Apparently the homologous antiserum, when combined with the d-ribonuclease inhibited the activity of the enzyme from 10 to 30 per cent.

Antigenicity of IgG was compared among human, the cynomolgus monkey, the African green monkey and the squirrel monkey by the quantitative precipitation test using purified IgG of and rabbit anti-IgG serum to each species. Clear cross-antigenicity was observed between the cynomolgus monkey and the African green monkey and less clear cross-antigenicity between human and the cynomolgus monkey or t...

BACKGROUND The ultra-large von Willebrand factor (vWF) multimers are very active and must be degraded by ADAMTS13 for optimal activity. A severe functional deficiency of ADAMTS13 has been associated with thrombotic thrombocytopenic purpura. The correct interpretation of patient vWF and ADAMTS13 plasma levels requires an understanding of the biological variation associated with these analytes. I...

Oxidative mechanisms are thought to have a major role in several biological phenomena, including cataract formation and diabetic complications. Here we investigate the inactivation of catalase and superoxide dismutase, both powerful antioxidant enzymes, by sugars of different glycating abilities, and the loss of antigenicity that was monitored by the loss of activity after immunoprecipitation w...

The antigenicity of foreign protein solutions complicates their employment either as plasma substitutes, or as nutritive agents. Recently interest has been aroused in the possibility of doing away with antigenicity, while retaining the great molecular weight of the protein. The present paper deals with the effects of light energy in the reduction of the antigenicity of horse serum, thus renderi...

Two hundred forty pyridazinamine derivatives were tested for the ability to stabilize the antigenicity and infectivity of oral poliovirus vaccine subjected to 45 degrees C for 2 h. Seven compounds stabilized the antigenicity of all three vaccine strains and neutralized the viral particles in a way that is reversible by dilution. Of these, R 77975 (pirodavir) was selected for vaccine potency tes...

expression of htlv-i p19 protein in an escherichia coli expression system always leads to the formation of inclusion body. solubilisation and refolding of the inclusion bodies is complex, time consuming and difficult during large-scale preparation. this study aimed to express and purify a soluble form of recombinant htlv-i p19 protein in an e. coli expression system. the synthetic dna encoding ...