Antiepileptics used for treating neuropathic pain have various actions including voltage-gated Na(+) and Ca(2+) channels, glutamate-receptor inhibition, and GABA(A)-receptor activation, while local anesthetics are also used to alleviate the pain. It has not been fully examined yet how nerve conduction inhibitions by local anesthetics differ in extent from those by antiepileptics. Fast-conductin...

Epilepsy is one of the common neurological disease affecting millions people worldwide. Multiple class antiepileptic drugs (AEDs) are available which makes it difficult to select an appropriate drug therapy for epilepsy. With introduction newer generation antiepileptics, Pool has become wider. Factors determine selection includes seizure type, adverse effect, drug-drug interaction, age, pregnan...

BACKGROUND We developed a micellar liquid chromatographic (MLC) procedure for the determination of three extensively monitored antiepileptics in serum samples: carbamazepine, phenobarbital, and phenytoin. METHODS We determined the composition of the mobile phase after modeling the elution behavior of the antiepileptics in hybrid micellar mobile phases of sodium dodecyl sulfate (SDS) with diff...

conclusions definite diagnosis of pnea not only reduces significantly unnecessary use of aeds (p = 0.001) and psychotropic drugs, but also increases patients’ productivity and emotional wellbeing. in addition, it leads them to accept diagnosis and follow appropriate treatment. objectives the aim of this study is to investigate occurrence of pnea in patients admitted to the razavi epilepsy depar...