BACKGROUND Cissampelos sympodialis (Menispermaceae), known as "Milona" has a specific verified medicinal use for the treatment of diarrhea and respiratory tract diseases. This work aims to evaluate the antimotility and antidiarrheal activity of crude ethanolic extract (EtOHE-Cs), and the total alkaloid fraction (TAF-Cs) obtained from aerial parts of C. sympodialis. METHODS Normal intestinal t...

Recent studies of the pathophysiology of diarrhea have resulted in both increased understanding of how existing antidiarrheal drugs work and a rational approach to the development of new antidiarrheal therapies. No longer can one assume that all antidiarrheal medicines are effective solely by virtue of their effects on intestinal smooth muscle with prolongation of intestinal transit time. The c...

The present-day concepts on the pathophysiology of secretory diarrhea (1) have opened a new stage in the pharmacological treatment of diarrhea in children. Drugs used in the past as antidiarrheal agents and believed to act only on intestinal motility are now being viewed as antisecretory compounds, and their antidiarrheal action is being attributed, at least partially, to their action on the fl...

Ethnopharmacological relevance of the study; Diarrhea remains one of the main killers of children aged below five years. Traditional antidiarrheal remedies form a potentially viable source of novel low cost efficacious antidiarrheal remedies in low resource settings. There is therefore a pressing to scientifically evaluate these remedies.

Diarrhea is one of the most common causes for thousands of deaths every year. Therefore, identification of new source of antidiarrheal drugs becomes one of the most prominent focuses in modern research. Our aim was to investigate the antidiarrheal and cytotoxic activities of methanolic extract of Maranta arundinacea linn. (MEMA) leaves in rats and brine shrimp, respectively. Antidiarrheal effec...

isovanillin and iso-acetovanillon are two phenolic components isolated from a number of plants including pycnocycla spinosa . p. spinosa extract has antispasmodic and antidiarrheal activities. however, no comparative study has been done on antidiarrheal action of isovanillin and iso- acetovanillon, so far. the aim of this study was to investigate antidiarrheal action of isovanillin and iso-acet...

background and objectives: calamus rotang is used in traditional medicine. regarding the previous phytochemical screening of methanol extract of calamus rotang l. fruits (mcr), this study was performed to find out the antidiarrheal and hypoglycemic effects of the experimented extract in rodents. methods: castor oil induced diarrheal test was followed for screening anti-diarrheal effect of mcr. ...

Objective: To analyse the antidiarrhoeal activity of Hemidesmatus indicus (L) R. Br root aqueous (HIRAE) and ethanolic (HIREE) extracts. Methods: HIRAE and HIREE at the dose of 100 and 200mg/kg bw was used to assess antidiarrheal activity in albino rats. Antidiarrheal activity was studied with reference to castor oil diarrhea for assessing faecal score, intestinal transit and enteropooling and ...

Wood creosote has long been used as an antidiarrheal agent, but its mechanism of action is not well understood. To elucidate the mechanism of its antidiarrheal activity, we have addressed questions whether it inhibits fluid secretion induced by Escherichia coli heat-stable enterotoxin (STa) in rabbit jejunum in vivo, and whether it inhibits muscle contraction of isolated rabbit ileum ex vivo. W...

To investigate the antidiarrheal activities of the methanolic extract of peel (MSPL) and pulp (MSPP) of Musa sapientum fruits, the extract was studied for antidiarrheal property using castor oil and magnesium sulphate induced diarrheal model and charcoal induced gastrointestinal motility as well as PGE -induced 2 enterolooping test in mice. In addition, activities against some causative diarrhe...