نتایج جستجو برای: anticonvulsant antitubercular

تعداد نتایج: 6799  

Journal: :iranian journal of pharmaceutical sciences 0
mohammad asif grd(pg)imt dehradun india anita singh department of pharmaceutical sciences, kumaun university, bhimtal, nainital india lakshmayya bilkanti grd (pg) institute of management and technology, dehradun, 248009, india

methyl indole derivative of some 6-aryl-4,5-dihydropyridazin-3(2h)-ones (3a-e) were synthesized by mannich reaction and evaluated as anticonvulsant against mes (50ma, for 2sec), inh (250mg/kg), scptz (80mg/kg) and str (3mg/kg) induced convulsion methods at 50 mg/kg dose level. all compounds 3a-e were also evaluated as antitubercular agent against m. tuberculosis h37rv by maba method. all compou...

Anita Singh Lakshmayya Bilkanti Mohammad Asif,

Methyl indole derivative of some 6-aryl-4,5-dihydropyridazin-3(2H)-ones (3a-e) were synthesized by Mannich reaction and evaluated as anticonvulsant against MES (50mA, for 2sec), INH (250mg/kg), scPTZ (80mg/kg) and STR (3mg/kg) induced convulsion methods at 50 mg/kg dose level. All compounds 3a-e were also evaluated as antitubercular agent against M. tuberculosis H37Rv by MABA method. All compou...

Journal: :Future Journal of Pharmaceuticals and Health Sciences 2021

Biologically active heterocyclic compounds comprise of largest & manifold family organic compounds. These include Quinolines, Quinazolines, Aminoquinolines, etc and their derivatives. They exhibit multi-faceted biological properties like analgesic, anti-inflammatory, anticonvulsant, antibacterial, antifungal, antidepressant, anticancer, antitubercular &antihistaminic. are considered to ...

2014
Mohammad Asif

Triazole is a five member heterocyclic nucleus has attracted a wide consideration in exploration for the new remedial agents. This nucleus acts very important role in biological fields for various biologically active molecules. The chemistry of triazole compounds has expected considerable interest due to their synthetic and effective biological properties likes analgesic, antinflammatory, antio...

2014
Mohammad Asif Anita Singh

Some 6-aryl-4,5-dihydropyridazin-3(2H)-one compounds (2a-f) were synthesized and evaluated for their in-vivo anticonvulsant activities against maximal electro shock (MES) and isoniazid (INH) induced seizure methods at 50mg/kg dose level. Neurotoxicity of all compounds (2a-f) was also tested at 50, 100 and 200mg/kg dose level. The in-vitro antitubercular activity was evaluated against Mycobacter...

2017
Sucheta Sumit Tahlan Prabhakar Kumar Verma

Thiazolidinediones are sulfur containing pentacyclic compounds that are widely found throughout nature in various forms. Thiazolidinedione nucleus is present in numerous biological compounds, e.g., anti-malarial, antimicrobial, anti-mycobacterium, anticonvulsant, antiviral, anticancer, anti-inflammatory, antioxidant, anti-HIV (human immunodeficiency virus) and antitubercular agent. However, owi...

Journal: :Molecules 2021

Pyridazine and thiazole derivatives have various biological activities such as antimicrobial, analgesic, anticancer, anticonvulsant, antitubercular other anticipated properties. Chitosan can be used heterogeneous phase transfer basic biocatalyst in heterocyclic syntheses. Novel 1-thiazolyl-pyridazinedione were prepared via multicomponent synthesis under microwave irradiation ecofriendly energy ...

Journal: :Acta pharmaceutica 2005
Surendra Nath Pandeya Sivakumar Smitha Mayank Jyoti Seshaiah Krishnan Sridhar

Isatin is an endogenous compound identified in humans that possesses a wide range of biological activities. Isatin has anxiogenic, sedative, anticonvulsant activities and acts as a potent antagonist on atrial natriuretic peptide receptors in vitro. A series of p-substituted isatin semicarbazones have shown anticonvulsant activity in MES, scPTZ and scSTY tests. Various isatin-N-Mannich bases of ...

Journal: :Journal of Drug Delivery and Therapeutics 2022

Due to its beneficial natural and pharmacological properties, heterocyclic element analogues derivatives have recently received a lot of attention. One the frequently occurring nuclei in both marine grow solutions is benzothiazole. A favoured bicyclist band method with numerous utilizations It well known for exhibiting broad variety activities, including those that are anticancer, antiviral, an...

Journal: :International journal of pharmaceutical chemistry and analysis 2023

Mannich bases are beta-amino ketone-carrying compounds that the end products of reaction. The reaction is essential in synthesis nitrogen-containing compounds. reaction, a nucleophilic addition forms carbon-carbon bonds, employed numerous natural products, drugs and other There several aminoalkyl chain bearing with high curative value, such as fluoxetine, atropine, ethacrynic acid, trihexypheni...

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