Crotalaria juncea (Leguminoceae) has been used for its antiarthritic effect in the folklore medicine. The purpose of this study was investigating experimentally the possible antiarthritic and antiulcerogenic properties of Crotalaria juncea leaves in animal model. Ethanolic extract of Crotalaria juncea (CJE) was administered at the doses of 200 and 400 mg/kg to complete Freund’s adjuvant (...

OBJECTIVES To formulate a polyherbal formulation and evaluate its antiarthritic activity against Freund's complete adjuvant induced arthritis in Female Wistar rats. MATERIALS AND METHODS Glycosmis pentaphylla, Tridax procumbens, and Mangifera indica are well-known plants available throughout India and they are commonly used for the treatment of various diseases including arthritis. The polyhe...

Present study was done to assess the in vitro antiarthritic activity of the plant Sphaeranthus amaranthoides Burm F (Asteracea). Four different extract of increasing polarity namely petroleum ether, chloroform, ethyl acetate and methanol were prepared. Antiarthritic potential of the plant was assessed by two methods namely, effect on protein denaturating and effect on membrane stabilization. Th...

Rodent models of immune-mediated arthritis (RMIA) are the conventional approach to evaluating mechanisms of inflammatory joint disease and the comparative efficacy of antiarthritic agents. Rat adjuvant-induced (AIA), collagen-induced (CIA), and streptococcal cell wall-induced (SCW) arthritides are preferred models of the joint pathology that occurs in human rheumatoid arthritis (RA). Lesions of...

The present study was designed to investigate anti-inflammatory and antiarthritic activities of ethanolic extract of male flowers (inflorescences) of Borassus flabellifer L (Arecaceae). Nystatin-induced rat paw edema model was employed to investigate the anti-inflammatory activity and Freund’s Complete Adjuvant (FCA) induced poly arthritis was used to screen antiarthritic potential of the extra...

BACKGROUND & OBJECTIVES Majoon Suranjan (MS) is a polyherbal formulation used in Unani system of medicine for the treatment of rheumatoid arthritis (RA). The present study evaluates the antiarthritic efficacy of this formulation in three different experimental models. METHODS The anti-inflammatory activity of MS (in doses of 450, 900 and 1800 mg/kg body wt) was evaluated using the turpentine ...

The present study was carried out to investigate the pharmacokinetics and pharmacodynamic interaction of Aceclofenac and Rosiglitazone alone and their combination in rats. The animals were maintained on standard laboratory conditions and were divided into 3 and 6 groups for pharmacokinetic and pharmacodynamic studies respectively. Aceclofenac and Rosiglitazone alone produced antiarthritic and m...

Recently, phosphatidylserine (PS) has received attention for its anti-inflammatory effect; however, the molecular mechanisms of its action have not been fully understood. Thus, we hypothesized that PS might have antiarthritic and anti-inflammatory effects. To test this hypothesis, the in vitro anti-inflammatory effect of soybean-derived PS was tested on interleukin (IL)-1β-stimulated fibroblast...