In this work, the solubilities of pharmaceutical cocrystals in solvent/anti-solvent systems were predicted using PC-SAFT in order to increase the efficiency of cocrystal formation processes. Modeling results and experimental data were compared for the cocrystal system nicotinamide/succinic acid (2:1) in the solvent/anti-solvent mixtures ethanol/water, ethanol/acetonitrile and ethanol/ethyl acet...

cinnamon is the bark the cinnamomi cassia that exhibits many medical properties such as anti-cancer effect and anti-diabetic effect. moreover, because of its antioxidant activity; it can be used in food industries. many studies have already reported biological and chemical properties of the cinnamon extracted essential oil such as their antimicrobial, antifungal, antimosquito, free radical scav...

The solvent displacement method involves three main steps to obtain nanoparticles: dissolution of both the polymer and the drug into a solvent, mixing of the obtained solution with the anti-solvent, and elimination of the solvent through evaporation. 1 Mixing leads to rapid diffusion of the solvent into the anti-solvent and spontaneous particle formation. Particle formation is extremely rapid a...

In recent years, significant effort has been devoted to the development of drug formulation with the purpose of targeting and controlled release. The micro/nanosizing of drugs has been identified as a potentially effective and broadly applicable approach. In the pharmaceutical industry several conventional techniques have been utilized for particle size reduction. The disadvantages of these tec...