نتایج جستجو برای: anti influenza agents

تعداد نتایج: 738542  

Journal: :iranian journal of pharmaceutical research 0
poonam inamdar department of pharmaceutical chemistry- pg wing, aissms college of pharmacy, pune-01, maharashtra, india. shashikant bhandari department of pharmaceutical chemistry- pg wing, aissms college of pharmacy, pune-01, maharashtra, india. bhagyashri sonawane department of pharmaceutical chemistry- pg wing, aissms college of pharmacy, pune-01, maharashtra, india. asha hole department of pharmaceutical chemistry- pg wing, aissms college of pharmacy, pune-01, maharashtra, india. chintamani jadhav department of pharmaceutical chemistry- pg wing, aissms college of pharmacy, pune-01, maharashtra, india.

the urgent need of neuraminidase inhibitors (ni) has provided an impetus for understanding the structure requisite at molecular level. our search for selective inhibitors of neuraminidase has led to the identification of pharmacophoric requirements at various positions around acyl thiourea pharmacophore. the main objective of present study is to develop selective ni, with least toxicity and dru...

2017
Xiaoai Wu Xiuli Wu Qizheng Sun Chunhui Zhang Shengyong Yang Lin Li Zhiyun Jia

The influenza pandemic is a major threat to human health, and highly aggressive strains such as H1N1, H5N1 and H7N9 have emphasized the need for therapeutic strategies to combat these pathogens. Influenza anti-viral agents, especially active small molecular inhibitors play important roles in controlling pandemics while vaccines are developed. Currently, only a few drugs, which function as influ...

Ebrahim Zabihi, Elham Amini, Mahsa Shahidi, Masoumeh Tavassoti Kheiri, Parvaneh Mehrbod, Seyed Masoud Hosseini,

There are many effective chemothereutic agents used in influenza disease which some of them inhibit virus replication by interfering with FluV (influenza virus) viral binding or its penetration into cell membrane. A series of polyoxometalates compounds such as POM-523 and PM-504 have been synthesized and have showed inhibitory effects on viruses. In this study we examined anti influenza activit...

Journal: :international journal of molecular and cellular medicine 0
seyed masoud hosseini department of microbiology, faculty of biological science, shahid beheshti university, evin, tehran, iran.سازمان اصلی تایید شده: دانشگاه شهید بهشتی (shahid beheshti university) elham amini influenza unit, pasteur institute of iran, 12 farvardin st. tehran, iran.سازمان اصلی تایید شده: انستیتو پاستور ایران (pasteur institute of iran) masoumeh tavassoti kheiri influenza unit, pasteur institute of iran, 12 farvardin st. tehran, iran.سازمان اصلی تایید شده: انستیتو پاستور ایران (pasteur institute of iran) parvaneh mehrbod influenza unit, pasteur institute of iran, 12 farvardin st. tehran, iran.سازمان اصلی تایید شده: انستیتو پاستور ایران (pasteur institute of iran) mahsa shahidi influenza unit, pasteur institute of iran, 12 farvardin st. tehran, iran.سازمان اصلی تایید شده: انستیتو پاستور ایران (pasteur institute of iran) ebrahim zabihi cellular and molecular biology research center (cmbrc), babol university of medical sciences, babol, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (babol university of medical sciences)

there are many effective chemothereutic agents used in influenza disease which some of them inhibit virus replication by interfering with fluv (influenza virus) viral binding or its penetration into cell membrane. a series of polyoxometalates compounds such as pom-523 and pm-504 have been synthesized and have showed inhibitory effects on viruses. in this study we examined anti influenza activit...

2010
Elena A. Govorkova Robert G. Webster

The emergence of pandemic H1N1 influenza viruses in April 2009 and the continuous evolution of highly pathogenic H5N1 influenza viruses underscore the urgency of novel approaches to chemotherapy for human influenza infection. Anti-influenza drugs are currently limited to the neuraminidase inhibitors (oseltamivir and zanamivir) and to M2 ion channel blockers (amantadine and rimantadine), althoug...

2014
Parvaneh Mehrbod Abdul Rahman Omar Mohd Hair-Bejo Amin Haghani Aini Ideris

The influenza virus (IV) is known to be a resistant virus with frequent mutations, causing severe respiratory diseases in the upper respiratory system. Public health concerns about clinical efficacy of all conventional drugs are ambiguous; therefore, finding additional therapeutic agents is critical to prevent and control influenza outbreaks. Influenza is associated with the induction of proinf...

Journal: :jundishapur journal of microbiology 0
deepak sharma department of biotechnology, indian institute of technology roorkee, roorkee 247667, india mohammad javed ansari department of biotechnology, indian institute of technology roorkee, roorkee 247667, india; bee research chair, department of plant protection, college of food and agriculture sciences, king saud university, riyadh 11451, ksa; department of plant protection, college of food and agriculture sciences, king saud university, riyadh 11451, ksa. tel: +966-1146796001, fax: +966-114693877 sonam gupta department of biotechnology, indian institute of technology roorkee, roorkee 247667, india ahmad al ghamdi bee research chair, department of plant protection, college of food and agriculture sciences, king saud university, riyadh 11451, ksa parul pruthi department of biotechnology, indian institute of technology roorkee, roorkee 247667, india vikas pruthi department of biotechnology, indian institute of technology roorkee, roorkee 247667, india

conclusions potato peels were proved to be potentially useful substrates for biosurfactant production by b. pumilus dsvp18. the strain possessed a unique property to reduce surface tension of the media from 72 to 28.7 mn/m. in addition, it showed a stable surface activity over a wide range of temperatures, ph, and saline conditions and had strong antimicrobial activity. this potential of the id...

2011
Mehran Haidari Wei Zhang Leila Ganjehei Muzammil Ali Zhenping Chen

Influenza A viruses are a severe threat worldwide, causing large epidemics that kill thousands every year. Prevention of influenza infection is complicated by continuous viral antigenic changes. Newer anti-influenza agents include MEK/ERK and protein kinase C inhibitors; however, the downstream effectors of these pathways have not been determined. In this study, we identified a common mechanism...

Journal: :Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006
David S Fedson

The next influenza pandemic may be imminent. Because antiviral agents and vaccines will be unavailable to people in most countries, we need to determine whether other agents could offer clinical benefits. Influenza is associated with an increase in acute cardiovascular diseases, and influenza viruses induce proinflammatory cytokines. Statins are cardioprotective and have anti-inflammatory and i...

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