a Drugs A and B have similar activity. a -l When the effective doses of A and B in combination are located in the area of m+n 1, m> 1, n> 1, they are called par tial antagonism. a -4 When they are located out of the square area, that is, m)1...

Previous investigations have demonstrated the ability of atropine and chlorpromazine pretreatment to increase intravenous cocaine self-administration in rhesus monkeys. These results were interpreted as resulting from either an antagonism of cocaine's reinforcing effect or an effect of cocaine which may interfere with its self-administration. The generality of the postulated drug antagonism was...

We have measured the competitive antagonistic effect of chlorpheniramine in bronchi of 8 normal and 12 asthmatic subjects. Classical pharmacological theory states that the degree of competitive antagonism depends only upon 1) antagonist concentration at the receptor, and 2) receptor affinity. Delivery and affinity also influence agonist responsiveness, but measurement of bronchial antagoni...

With techniques and materials previously described5 a number of lactones (both naturally occurring and synthetic), and some related compounds, have been shown to have definite in vitro trypanocidal activity. It was further shown that these compounds have therapeutic effect in vivo. The concept that specific chemical substances can interfere with the action of a chemotherapeutic agent provides a...

The way the parents build their relationships with their children is the strongest factor affecting family interaction patterns. This study aimed to examine the role of maternal parenting styles in predicting oppositional defiant, behavior, conduct, mood, and separation anxiety disorders among elementary school students. In this research, 86 children among all those referring to the counseling ...

Either 5-HT2A antagonism or fast dissociation from D2 receptors may define an atypical antipsychotic. To have little or no motor symptoms from an antipsychotic, it is clear that D2 receptor binding in the striatum must be less than that caused by conventional antipsychotics. Pure 5-HT2A antagonism by itself does not result in robust antipsychotic actions. However, 5-HT2A antagonism can reduce D...