OBJECTIVE This in-vitro study was designed to measure the quantity of acid neutralized by a suspension of a commercial antacid available in Indian markets at a labeled dose and to test the concept of the relative effectiveness of 7 different commercial antacids containing Oxethazaine. METHODS A simple back titration methodology was used to determine the acid neutralization capacity (ANC) of a...

The effect of antacids on the dissolution behaviour of methacycline and doxycycline capsules from commercial dosage forms were studied. The dissolution of both tetracyclines was found to be markedly retarded by antacids such as magnesium trisilicate and magnesium oxide. An attempt was made to elucidate the mechanism of this effect. The results suggest that the effect of antacids on the dissolut...

Objective: To determine and verify the acid neutralization capacity (ANC) of antacid preparations sold across various retail pharmacies in UAE. Another important objective is to quantify the amount of sodium, calorific content, overall monthly consumption and cost of therapy with respect to its composition and manufacturer. Materials and Methods: In Vitro analysis was carried out on various ant...

BACKGROUND Over-the-counter histamine-2 receptor antagonists, antacids and alginate/antacids are commonly used for gastro-oesophageal reflux disease. AIM To conduct a systematic review and meta-analysis of related treatment trials. METHODS We performed a systematic search and abstraction of randomized, placebo-controlled trials conducted during 1972-2005. Study quality was measured by the J...

The rate of gastric emptying of two antacids, magaldrate and Maalox, was investigated using scintigraphy. Successful labelling of the antacids was carried out with 99mTc. The stability of the 99mTc-labelled antacids was satisfactory and there was no difference in antacid capacity between the labelled and unlabelled antacids. The studies were carried out on 15 healthy male volunteers. After an e...