نتایج جستجو برای: angiotensins

تعداد نتایج: 23319  

Journal: :Journal of Molecular Medicine 2008

2012
O.N. Solopova L.P. Pozdnyakova N.E. Varlamov M.N. Bokov E.V. Morozkina Т.А. Yagudin P.G. Sveshnikov

The peptide conformation in the context of a protein polypeptide chain is influenced by proximal amino acid residues. However, the mechanisms of this interference remain poorly understood. We studied the conformation of angiotensins 1, 2 and 3, which are produced naturally in a sequential fashion from a precursor protein angiotensinogen and contain an identical peptide core structure. Using the...

Journal: :Circulation research 1990
S S Tang L Stevenson V J Dzau

Cultured bovine aortic endothelial cells (BAECs) express the complete renin-angiotensin system and secrete angiotensins. In this study, we examined the adrenergic influence on the secretion of angiotensins from BAECs. Angiotensins were determined by high-performance liquid chromatography and radioimmunoassay. At basal state, BAECs contain angiotensin I, angiotensin II, and angiotensin III at co...

Journal: :Rheumatology Science and Practice 2019

Journal: :Hypertension 2015

Journal: :Acta neurologica Belgica 2009
Alin Ciobica Walther Bild Lucian Hritcu Ion Haulica

Biochemical, physiological and functional studies suggest that the brain renin-angiotensin system (RAS) is regulated independently of the peripheral RAS. Also, all enzymes and peptides necessary for the biosynthesis of various angiotensins have been recognized within the central nervous system. There are divergent opinions concerning the localization of the different components of this system w...

Journal: :Hypertension 1991
K Higashimori J Gante G Holzemann T Inagami

The effects of specific renin inhibitors, angiotensin converting enzyme inhibitors, indomethacin, and prostaglandin I2 analogue on the release of angiotensins from isolated and Krebs-Ringer-perfused rabbit mesenteric arteries were examined. Three different renin inhibitors suppressed release of angiotensins in dose-dependent manners. At the highest concentration (10(-7) M), the inhibitors EMD 5...

Journal: :American journal of physiology. Heart and circulatory physiology 2016
Mark C Chappell

REPLY: Although I appreciate the comments from Poglitsch and colleagues in their letter (5), their assertion that my review concluded that liquid chromatography-mass spectrometry (LCMS) lacks the sensitivity to quantify endogenous angiotensins and requires exogenous renin for peptide detection is surprising and quite incorrect. I discussed multiple LC-MS studies that quantified angiotensins in ...

Journal: :Circulation research 1982
W A Rightsel T Okamura T Inagami J A Pitcock Y Takii B Brooks P Brown E E Muirhead

A monolayer cell culture of juxtaglomerular cells (JGC) was derived from the renal cortex of neonatal rats. The JGC had the characteristics of those within the kidney, including peripheral dense bodies and myofibrils indicating a smooth muscle origin; rough ER containing fluffy material consistent with protein synthesis; a prominent Golgi apparatus for packaging granules, and granules having th...

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