introduction: anesthetic agents, blood pressure, arterial ph and blood gases have found to influence on the pathophysiology of experimental stroke. despite, there are very few comparative studies about effects of anesthetic agents in animal model of cerebral ischemia. therefore, in this study, we investigated the effects of chloral hydrate and pentobarbital anesthesia, as comparative study, on ...

background: injection of local anesthesia is one of the most important reasons for development of avoidance behavior in children. efforts have been performed to decrease pain perception of injection. the present research evaluated the effect of cooling the injection site on pain perception before infiltration of local anesthetics. materials and methods: a prospective single-blind crossover clin...

local anesthesia forms the major part of pain-control techniques in dentistry. the prevention and elimination of pain during dental treatment has benefited patients, their doctors and dental hygienists, enabling the dental profession to make tremendous therapeutic advances that would otherwise have been impossible. introduced in the late 1940s, the amide local anesthetics represent the most use...

Corresponding author: Sungsik Park, M.D., Ph.D., Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, Samduk-2 ga, Joong-gu, Daegu 700-721, Korea. Tel: 82-53-420-5863, Fax: 82-53-426-2760, E-mail: [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativeco...

conclusions hepatotoxicity of halogenated inhalational anesthetics has been well documented in available literature. halothane-induced liver injury was extensively acknowledged; however, the next generation halogenated anesthetics have different molecular structures and associated with less hepatotoxicity. although anesthesia-induced hepatitis is not a common occurrence, we must consider the as...

Anesthesia for electroconvulsive therapy (ECT) usually involves the intravenous (IV) administration of drugs such as methohexital, thiopental, propofol, etomidate, or ketamine. Sevoflurane is an inhalational anesthetic agent that has been available past 3 decades. Although many studies have examined sevoflurane in context ECT, treatment guidelines make either no mention only passing its potenti...

pain is a challenging health dilemma and has gained a great focus in clinico-pathological conditions correlated with post-operative, neuropathic and cancer pain. while perioperative administration of analgesics to mitigate the postoperative pain has been well established in the literature (termed preventive analgesia), preemptive analgesia or effects of any drug (such as anesthetics) prior to o...

BACKGROUND Volatile anesthetics induce pharmacological preconditioning in cardiac tissue. The purpose of this study was to test whether volatile anesthetics mediate this effect by activation of the mitochondrial adenosine triphosphate-sensitive potassium (mitoK(ATP)) or sarcolemmal K(ATP) (sarcK(ATP)) channel in rat ventricular myocytes and to evaluate the signaling pathways involved. METHODS...

Current concepts of the molecular and cellular mechanisms that underlie general anesthetic actions are incomplete. This is both surprising, given that leading scientists have approached this problem for more than a century, and unfortunate since this lack of knowledge limits our ability to employ these important drugs with optimal safety and efficacy. Considerable evidence now implicates agent-...