نتایج جستجو برای: anergy

تعداد نتایج: 1795  

2012
Yan Zheng Yuanyuan Zha Gregory Driessens Frederick Locke Thomas F. Gajewski

T cell receptor engagement in the absence of costimulation results in a hyporesponsive state termed anergy. Understanding the transcriptional regulation of other T cell differentiation states has provided critical information regarding the biology of T cell regulation in vivo. However, the transcriptional regulation of T cell anergy has been poorly understood. Using the key anergy target gene d...

Journal: :The Journal of clinical investigation 2001
A D Wells M C Walsh J A Bluestone L A Turka

Primary T cell proliferative responses to TCR ligation plus CD28 costimulation are surprisingly heterogeneous. Many cells that enter G1 fail to progress further through the cell cycle, and some of these cells subsequently fail to divide upon restimulation, even in the presence of IL-2. Such IL-2-refractory anergy is distinct from the IL-2-reversible anergy induced by TCR occupancy in the absenc...

Journal: :archives of clinical infectious diseases 0
shervin shokuhi department of infectious diseases & tropical medicine, loghman hakim hospital, shahid beheshti medical university, tehran, ir iran. email: effat nikfarjam shirazi ali ali asgari department of internal medicine, loghman hakim hospital, shahid beheshti medical university, tehran, ir iran latif gachkar

conclusion skin test anergy is uncommon among drug users and the ppd skin test may be reliably used for the identification of latent tb infection in the population. results a total of 221 patients (216 male, mean age 43.5 ± 14.3 years) were studied. tuberculin skin test results showed that 87 subjects (39.4%) tested positive for tb reactivity. reactivity to tetanus and candida antigens were obs...

Journal: :Journal of immunology 2008
Sarat K Dalai Saied Mirshahidi Alexandre Morrot Fidel Zavala Scheherazade Sadegh-Nasseri

Induction of tolerance in memory T cells has profound implications in the treatment of autoimmune diseases and transplant rejection. Previously, we reported that the presentation of low densities of agonist peptide/MHC class II complexes induced anergy in memory CD4(+) T cells. In the present study, we address the specific interaction of different types of APCs with memory CD4(+) T cells. A nov...

Journal: :Journal of immunology 2006
Robert A Barrington Madhuri Borde Anjana Rao Michael C Carroll

B cells from anti-lysozyme Ig/soluble lysozyme double-transgenic mice are chronically exposed to self-Ag in the periphery, resulting in an anergic phenotype. Chronic exposure to self-Ag leads to nuclear translocation of NFAT1 and NFAT2, suggesting that they are involved in anergy. To directly test a role for NFAT1 in B cell anergy, NFAT1-deficient mice were crossed with anti-lysozyme Ig transge...

2015
Yu Mi Oh Hyung Bae Park Jae Hun Shin Ji Eun Lee Ha Young Park Dhong Hyo Kho Jun Sung Lee Heonsik Choi Tomohiko Okuda Koichi Kokame Toshiyuki Miyata In-Hoo Kim Seung Hoon Lee Ronald H. Schwartz Kyungho Choi

Induction of T-cell clonal anergy involves serial activation of transcription factors, including NFAT and Egr2/3. However, downstream effector mechanisms of these transcription factors are not fully understood yet. Here we identify Ndrg1 as an anergy factor induced by Egr2. Ndrg1 is upregulated by anergic signalling and maintained at high levels in resting anergic T cells. Overexpression of Ndr...

Journal: :Journal of immunology 2004
Saied Mirshahidi Laura C Korb Ferris Scheherazade Sadegh-Nasseri

Fast dissociation rate of peptide-MHC complexes from TCR has commonly been accepted to cause T cell anergy. In this study, we present evidence that peptides that form transient complexes with HLA-DR1 induce anergy in T cell clones in vitro and specific memory T cells in vivo. We demonstrate that similar to the low densities of long-lived agonist peptide-MHC, short-lived peptide-MHC ligands indu...

2012
Brian T. Abe Daniel S. Shin Enric Mocholi Fernando Macian

Cancer cells express antigens that elicit T cell-mediated responses, but these responses are limited during malignant progression by the development of immunosuppressive mechanisms in the tumor microenvironment that drive immune escape. T-cell hyporesponsiveness can be caused by clonal anergy or adaptive tolerance, but the pathophysiological roles of these processes in specific tumor contexts h...

Journal: :Cancer research 2012
Brian T Abe Daniel S Shin Enric Mocholi Fernando Macian

Cancer cells express antigens that elicit T cell-mediated responses, but these responses are limited during malignant progression by the development of immunosuppressive mechanisms in the tumor microenvironment that drive immune escape. T-cell hyporesponsiveness can be caused by clonal anergy or adaptive tolerance, but the pathophysiological roles of these processes in specific tumor contexts h...

Journal: :Journal of immunology 1999
L S Taams W van Eden M H Wauben

T cell anergy has been proposed as one of the mechanisms underlying peripheral T cell tolerance. In recent years, the functional relevance of T cell anergy has been studied extensively in vitro and in vivo, using different species, cell systems, and ways to induce anergy. Although these studies concurred about the induction of unresponsiveness, conflicting findings were obtained with respect to...

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