نتایج جستجو برای: and ns5a proteins

تعداد نتایج: 16874701  

Journal: :middle east journal of digestive diseases 0
mohammadreza fattahi abdorrasoul malekpour mojtaba mortazavi alireza safarpour nasrin naseri

background recent studies suggest that rare codon clusters are functionally important for protein activity. methods here, for the first time we analyzed and reported rare codon clusters in hepatitis c virus (hcv) genome and then identified the location of these rare codon clusters in the structure of hcv protein. this analysis was performed using the sherlocc program that detects statistically ...

پایان نامه :دانشگاه آزاد اسلامی - دانشگاه آزاد اسلامی واحد علوم دارویی - پژوهشکده علوم 1392

purpose a metabolic abnormality such as obesity is a major obstacle in the maintenance of the human health system and causes various chronic diseases including type 2 diabetes, hypertension, cardiovascular diseases, as well as various cancers. this study was designed to summarize the recent scientific knowledge regarding the anti-obesity role of curcumin (diferuloylmethane), which is isolated f...

Journal: :Journal of virology 2001
S J Polyak K S Khabar D M Paschal H J Ezelle G Duverlie G N Barber D E Levy N Mukaida D R Gretch

Hepatitis C virus (HCV), a major cause of liver disease worldwide, is frequently resistant to the antiviral alpha interferon (IFN). The HCV nonstructural 5A (NS5A) protein has been implicated in HCV antiviral resistance in many studies. NS5A antagonizes the IFN antiviral response in vitro, and one mechanism is via inhibition of a key IFN-induced enzyme, the double-stranded-RNA-activated protein...

2017
Niluka Goonawardane Anna Gebhardt Christopher Bartlett Andreas Pichlmair Mark Harris

Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a phosphoprotein that plays key, yet poorly defined, roles in both virus genome replication and virion assembly/release. It has been proposed that differential phosphorylation could act as a switch to regulate the various functions of NS5A; however, the mechanistic details of the role of this posttranslational modification in the virus ...

2016
Fredrik Holmström Margaret Chen Anangi Balasiddaiah Matti Sällberg Gustaf Ahlén Lars Frelin

The hepatitis C virus nonstructural (NS) 3/4A and NS5A proteins are major targets for the new direct-acting antiviral compounds. Both viral proteins have been suggested as modulators of the response to the host cell. We have shown that NS3/4A- and NS5A-specific T cell receptors confer different effector functions, and that killing of NS3/4A-expressing hepatocytes is highly dependent on IFN-γ. W...

Journal: :The Journal of biological chemistry 2004
Timothy L Tellinghuisen Joseph Marcotrigiano Alexander E Gorbalenya Charles M Rice

The NS5A protein of hepatitis C virus is believed to be an integral part of the viral replicase. Despite extensive investigation, the role of this protein remains elusive. Only limited biochemical characterization of NS5A has been performed, with most research to date involving the myriad of host proteins and signaling cascades that interact with NS5A. The need for better characterization of NS...

Journal: :The Journal of general virology 2013
Andrea Galli Troels K H Scheel Jannick C Prentoe Lotte S Mikkelsen Judith M Gottwein Jens Bukh

Hepatitis C virus (HCV) is an important human pathogen infecting hepatocytes. With the advent of infectious cell culture systems, the HCV particle assembly and release processes are finally being uncovered. The HCV core and NS5A proteins co-localize on cytoplasmic lipid droplets (cLDs) or on the endoplasmic reticulum (ER) at different stages of particle assembly. Current knowledge on assembly a...

Journal: :Journal of virology 1995
Y Tanji T Kaneko S Satoh K Shimotohno

Two proteins, a 56-kDa protein (p56) and a 58-kDa protein (p58), are produced from the hepatitis C virus (HCV) nonstructural region 5A (NS5A). Recently, we found that both proteins are phosphorylated at serine residues and that p58 is a hyperphosphorylated form of p56. Furthermore, hyper-phosphorylation depends on the production of an intact form of the HCV NS4A protein. To clarify the nature o...

Journal: :The Journal of general virology 2007
Daniel M Jones Sarah N Gretton John McLauchlan Paul Targett-Adams

We have introduced GFP and photoactivatable GFP into the NS5A coding region of a hepatitis C virus (HCV) subgenomic replicon that gives efficient transient replication. NS5A-GFP, expressed by the replicon, could be detected in cytoplasmic fluorescent foci as early as 4 h after RNA was introduced into cells. The fluorescent foci are likely to be sites where RNA synthesis could occur, although th...

Journal: :The Journal of general virology 2001
C M Johnson D R Perez R French W C Merrick R O Donis

A cellular protein that interacts with the NS5A polypeptide of bovine viral diarrhoea virus (BVDV) was identified in a yeast two-hybrid screen. The NS5A interactor was identified as the alpha subunit of bovine translation elongation factor 1A (eEF1A). Cell-free binding studies were performed with chimeric NS5A fused to glutathione S-transferase (GST-NS5A) expressed in bacteria. GST-NS5A bound s...

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