background & objectives: anaplastic lymphoma kinase (alk) is a receptor tyrosine kinase involved in the genesis of several human cancers. alk was initially identified because of its involvement in anaplastic large cell lymphoma (alcl). alk is believed to foster tumorigenesis following activation by autocrine and/or paracrine growth loops. studies reveal that the presence of anti-alk antibod...

abstract inflammatory pseudotumour describes as a wide range of neoplastic and reactive lesions. one of the rare presentations of these tumors is found in the salpinx. this case report characterizes a thirty six year old woman with a history of left sided abdominal pain for a few months. further examinations revealed that she had a complex cyst in her left salpinx. the patient had normal levels...

Primary breast lymphoma represents less than 1% of all primary breast malignancies and most primary breast lymphomas are of B-Cell origin. The association of anaplastic lymphoma kinase (ALK) negative anaplastic large cell lymphoma (ALCL), a very rare form of primary breast lymphoma, with silicone-filled breast implants has been suggested and several case reports supported this proposal, especia...

  Background and Objective: Inflammatory pseudotumor  is a lesion composed of proliferating spindle cells with mixed inflammatory infiltrates. Some authors have proposed the name inflammatory myofibroblastic tumor as a proper descriptive term rather than the vague inflammatory pseudotumor. The aim of this study was to verify the myofibroblastic origin of spindle cells in idiopathic orbital inf...

background and objective: inflammatory pseudotumor  is a lesion composed of proliferating spindle cells with mixed inflammatory infiltrates. some authors have proposed the name inflammatory myofibroblastic tumor as a proper descriptive term rather than the vague inflammatory pseudotumor. the aim of this study was to verify the myofibroblastic origin of spindle cells in idiopathic orbital inflam...

primary breast lymphoma represents less than 1% of all primary breast malignancies and most primary breast lymphomas are of b-cell origin. the association of anaplastic lymphoma kinase (alk) negative anaplastic large cell lymphoma (alcl), a very rare form of primary breast lymphoma, with silicone-filled breast implants has been suggested and several case reports supported this proposal, especia...

Abstract Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare, non-Hodgkin which arises within the capsules of breast implants. These particular tumours have expression CD30 and are negative for Anaplastic Lymphoma Kinase (ALK). Here, we report case BIA-ALCL in 48-year-old woman post reconstruction. This aimed at raising awareness education on significance considering d...

Anaplastic lymphoma kinase-positive anaplastic large T-cell lymphoma is characterized by morphological variability. Morphological variants (non-common subtype) are associated with a poor outcome. They display abundant reactive bystander cells admixed with the lymphoma cells. So far, the difficulty in distinguishing lymphoma cells from bystander cells by visual inspection has prevented detailed ...

Currently, a standard therapy has not been established for recurrent or refractory anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. While there are many treatment options, such as hematopoietic stem cell transplantation, patients with resistant disease to conventional chemotherapies have particularly poor prognosis. There is urgent need to develop new drugs because of the lac...

Patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma often present with B-symptoms or hemophagocytosis and generate an anti-tumor immune response. Specific serum cytokine levels or profiles may reflect the tumor burden, non-specific immune stimulation by the tumor or differences in the strength of the patients' anti-lymphoma immunity. We systematically correlated pre...