background post laparoscopic cholecystectomy pain management can reduce recovery and discharge time. non-steroidal anti-inflammatory drugs and opioids are used for this purpose. objectives this randomized clinical trial evaluates the efficacy of diclofenac rectal suppository for the management of postoperative pain. patients and methods forty four patients were randomized to receive either 100 ...

abstract background and objective: pain relief during labour is an important determinant of a women’s birth experience. there are numerous pain relief techniques which can be used either with or without pain medication. the aim of our study was to compare the effect of remifentanil alone and its effect in pain relief while using with ketamine during labour. methods: after obtaining informed con...

results the pain score was lower in group a (p= 0.01), but the morphine consumption showed no significant difference between the groups (p= 0.24) during the first 6 hours postoperatively. conclusions although paracetamol (1gr) has caused a better pain relief quality but it is not a suitable analgesic for moderate pain control in acute phase after surgery alone. background although opioids are t...

OBJECTIVES This study investigates utilisation patterns for prescription opioid analgesics in the Australian community and how these are associated with a framework of individual-level factors related to healthcare use. METHODS Self-reported demographic and health information from participants in the 45 and Up Study cohort were linked to pharmaceutical claims from 2006-2009. Participants comp...

KEY FINDINGS Data from the National Vital Statistics System Mortality File. From 1999 through 2006, the number of fatal poisonings involving opioid analgesics more than tripled from 4,000 to 13,800 deaths. Opioid analgesics were involved in almost 40% of all poisoning deaths in 2006. In 2006, the rate of poisoning deaths involving opioid analgesics was higher for males, persons aged 35-54 years...

Intensive research on the neurobiology of pain over the past two decades has revealed many receptors, ion channels and enzymes with potential as novel targets for development of a new generation of analgesic agents. However, despite large investment in preclinical and clinical development of small molecules and biologics as potential novel pain therapeutics, very few have reached the clinic. He...

Background Drug overdose mortality, particularly involving opioid analgesics, has risen steadily over the past two decades and is now the leading cause of injury death in the United States. Benzodiazepines are commonly prescribed concurrently to individuals receiving opioid analgesics. Little is known about the association between benzodiazepine-prescribing patterns and overdose mortality in th...

This study updates a previous analysis of trends in medical use and abuse of opioid analgesics, and provides data from 1997 through 2002. Two research questions were evaluated: 1) What are the trends in the medical use and abuse of frequently prescribed opioid analgesics used to treat severe pain, including fentanyl, hydromorphone, meperidine, morphine, and oxycodone? 2) What is the abuse trend...