OBJECTIVES To elucidate the dynamics of analgesic consumption regarding intravenous patient controlled analgesia (IVPCA) during postoperative period is rather complex partly due to between-patient variation and partly due to within-patient variation. A statistical method was proposed to classify serial analgesic consumption into different classifications that were further taken as the multiple ...

Perioperative analgesic strategies are frequently tested using analgesic consumption as an outcome measure. This outcome measure is intuitive and superficially attractive, but has not been evaluated rigorously. Flaws in its use may be one explanation of continuing controversies surrounding the efficacy of analgesic strategies tested by this method. We contend that the analgesic consumption outc...

BACKGROUND Reduction in consumption of opioid rescue medication is often used as an endpoint when investigating analgesic efficacy of drugs by adjunct treatment, but appropriate methods are needed to analyze analgesic consumption in time. Repeated time-to-event (RTTE) modeling is proposed as a way to describe analgesic consumption by analyzing the timing of consecutive analgesic events. METHO...

normal 0 false false false en-us x-none ar-sa background: the purpose of the present study was to determine the post-operative analgesic effects of preemptive intravenous (iv) paracetamol and the amount of reduction in tramadol (contramal ® ) consumption. materials and methods: following local research ethics committee approval, asai-ii, 300 patients were assigned in a randomized manner into th...

background: laparascopic surgery is associated with post operative pain .optimal pain treatment with minimal side effects is essential for early recovery and mobility in patients undergoing laparoscopic surgery .we compaired the analgesic effect pregabalin and gabapentin with different doses in this surgical procedurs.methods: in a randomized , double blind , ninety patients were  allocated to ...

Many factors affect individual variability in postoperative pain. Although several statistical studies have evaluated postoperative pain and analgesic consumption, previous research shows that the coefficient of determination of existing predictive models was small (e.g., R = 0.17–0.59 for postoperative pain, and 0.27–0.46 for postoperative analgesic consumption). This study presents the real-w...

Whether preemptive analgesic interventions are more effective than conventional regimens in managing acute postoperative pain remains controversial. We systematically searched for randomized controlled trials that specifically compared preoperative analgesic interventions with similar postoperative analgesic interventions via the same route. The retrieved reports were stratified according to fi...

UNLABELLED We evaluated in a qualitative systematic review the effect of N-methyl-D-aspartate (NMDA) receptor antagonists on reducing postoperative pain and analgesic consumption beyond the clinical duration of action of the target drug (preventive analgesia). Randomized trials examining the use of an NMDA antagonist in the perioperative period were sought by using a MEDLINE (1966-2003) and EMB...