In this study, the effect of an experimentally increased excitability in hippocampal neurons, via hippocampal kindling, on amygdala kindling rate was investigated in rats. Animals were divided into 4 groups. In all groups, except group 2, tripolar electrodes were implanted in the amygdala and CAI region of the dorsal hippocampus. Group 2 animals were only implanted with tripolar electrodes in...

Introduction: Many studies have shown that amygdala kindling produces synaptic potentiation by induction of changes in the neuronal electrophysiological properties and inward currents both in epileptic focus and in the areas which are in connection with the epileptic focus and have important role in seizure development and progression such as hippocampal CA1 region. However, cellular mechani...

introduction: many studies have shown that amygdala kindling produces synaptic potentiation by induction of changes in the neuronal electrophysiological properties and inward currents both in epileptic focus and in the areas which are in connection with the epileptic focus and have important role in seizure development and progression such as hippocampal ca1 region. however, cellular mechanisms...

Introduction: Considering the antiepileptogenic effects of repeated transcranial magnetic stimulation (rTMS), the effect of rTMS applied during amygdala kindling on spontaneous activity of hippocampal CA1 pyramidal neurons was investigated. Materials and Methods: A tripolar electrode was inserted in basolateral amygdala of Male Wistar rats. After a recovery period, animals received daily kindl...

Amygdala kindling is a model of temporal lobe epilepsy (TLE) with convulsion. The rapid amygdala kindling has an advantage on quick development of motor seizures and for antiepileptic drugs screening. The rapid amygdala kindling causes epileptogenesis accompanied by an anxiolytic response in early isolation of rat pups or depressive behavior in immature rats. However, the effect of rapid amygda...

Background: Although hydro-alcoholic extracts of Anethum graveolens L. had Anticonvulsants effect on PTZ-induced kindling seizure behavior, but on the amygdala kindling in rats induced seizure has not been investigated. Objective: In this study, we evaluated the chronic effects of hydro-alcoholic extracts of Anethum graveolens L. on seizures using electrical amygdala kindling model. Methods: ...

Amygdala kindling is useful for modeling human epilepsy development. It has been known that genetic factors are involved in the development of amygdala kindling. The purpose of this study was to identify the loci that are responsible for the development of amygdala kindling. To achieve this, rat strains from a LEXF/FXLE recombinant inbred (RI) strain panel were used. The phenotypes of amygdala ...

low frequency stimulation (lfs) is a potential alternative therapy for epilepsy. however, it seems that the anticonvulsant effects of lfs depend on its target sites in the brain. thus, the present study was designed to compare the anticonvulsant effects of lfs administered to amygdala, piriform cortex and substantia nigra on amygdala kindling acquisition. in control group, rats were kindled in ...

introduction: considering the antiepileptogenic effects of repeated transcranial magnetic stimulation (rtms), the effect of rtms applied during amygdala kindling on spontaneous activity of hippocampal ca1 pyramidal neurons was investigated. materials and methods: a tripolar electrode was inserted in basolateral amygdala of male wistar rats. after a recovery period, animals received daily kindli...

introduction: the claustrum interconnects with the allocortical and neocortical regions and also projects to the hippocampus and the amygdala. .the role of claustrum in the complex partial seizure is not clear. thus in this study the effect of amygdala lesion on anterior claustrum kindled seizures in rat were investigated. methods: male wistar rats, weighting 250-300 g, were received dc current...