نتایج جستجو برای: ampk
تعداد نتایج: 8651 فیلتر نتایج به سال:
objective(s): tlr-4 activates a number of inflammatory signaling pathways. also, ampk could be involved in anti-inflammatory signaling. the aim of this study was to identify whether stimulation of ampk could inhibit lps-induced tlr-4 gene expression in mice hearts. materials and methods: heart ampk activity and/or tlr-4 expression was stimulated in different mice groups, using respectively ip i...
Introduction: AMP activated protein kinase (AMPK) as key regulators of cell metabolism, plays a major role in the activation of catabolic pathways, such as glucose transport and fatty acid oxidation. Thus, activation of this pathway can be used in the treatment of diabetes and metabolic syndrome. Many studied proposed the effectiveness of the polyphenols present in rhizomes of turmeric (curcumi...
مقدمه: کیناز وابسته بهamp (ampk) به عنوان تنظیم کننده اصلی متابولیسم سلول، نقش عمده ای در فعال کردن مسیرهای کاتابولیک نظیر جابه جایی گلوکز و اکسیداسیون اسید چرب دارد. بنابراین فعال کنندگان این مسیر می تواند در درمان سندرم های متابولیک و دیابت کاربرد داشته باشد. مطالعات مختلف حاکی از مؤثر بودن پلی فنول موجود در ریززوم زردچوبه (کورکومین) بر دیابت و عوارض مرتبط با آن است. این مطالعه به بررسی اثر ک...
Objective(s): AMP-activated protein kinase/sirtuin 1 (AMPK/SIRT1) signaling pathway has been proved to be involved in the regulation of autophagy in various models. The aim of this study was to evaluate the effect of AMPK/SIRT1 pathway on autophagy after spinal cord injury (SCI). Materials and Methods:The SCI model was established in rats in vivo and the primary spinal cord neurons were subject...
Objective(s): TLR-4 activates a number of inflammatory signaling pathways. Also, AMPK could be involved in anti-inflammatory signaling. The aim of this study was to identify whether stimulation of AMPK could inhibit LPS-induced Tlr-4 gene expression in mice hearts. Materials and methods: Heart AMPK activity and/or Tlr-4 expression was stimulated in different mice groups, using respectively IP i...
HCC is marked by genetic heterogeneity and activated hepatic stellate cells (HSC) are considered key players during development. The paracrine effect of different cell lines on the activation primary hHSC was accompanied differential AMPK depending line used. Pharmacological treatment inhibited HCC-induced through AMPK-dependent AMPK-independent mechanisms. This heterogenic confirmed data minin...
Introduction: Blood glucose is high in diabetic patients. It is taken from blood by two separate pathways: Insulin-dependent pathway of phosphoinositide 3 kinase (PI3K) and insulin-independent pathway AMPK (AMP-Activated protein kinase). The first pathway is impaired in type 2 diabetic patients, but the second pathway is active. On the other hand, curcuma longa extract containing a high percent...
Background: AMPK regulation is one of biggest target in T2D and metabolic syndrome research. Therefore, the present study is aimed to investigate The effect of 8 weeks aerobic and Resistance training on AMP-activated protein kinase (AMPK) gene expression in soleus muscle and insulin resistance of STZ-induced diabetic rat. Methods: The research method of present study was experimental. For this...
conclusions according to the results, ud is able to decrease glucose level and improve insulin release in t2dm. in addition, as ud is able to induce a small increase in ampk activity, it is possible that the anti-hyperglycemic effect of ud is mediated by insulin secretion and the possible changes in ampk levels. results fbg levels of the drug group were significantly decreased compared with the...
Chronic muscle loading (overload) induces skeletal muscles to undergo hypertrophy and increase glucose uptake. Although AMP-activated protein kinase (AMPK) reportedly serves as a negative regulator of positive uptake, its role in overload-induced uptake is unclear. This study aimed determine whether AMPK regulates muscles. To this end, overload was induced through unilateral synergist ablations...
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