objective: amphotericin b (amb) is an ancient antifungal drug and proper for treatment of systemic fungal infection. unfortunately, this antibiotic has shown some side effects such as nephrotoxicity. therefore, recently new amb formulated has been prepared for reduced toxicity and increased effectiveness. materials and methods: amb nanocapsules prepared from polymers such as poly d, l-lactide-...

Objective: The main goal of study was finding the synergism effect of amphotricin B (AMB) and rifampin (RIF) on 3 species of Aspergillus. Methodology: Activities of amphotericin B in combination with rifampin were tested in buffered yeast-nitrogen base using checkerboard method. Plates were inoculated with 20μl spores suspensions of each organism and incubated at 30°C for 24h. For this method, ...

chronic granulomatous disease is an infrequent primary immunodeficiency characterized by defective intracellular killing of ingested microorganisms thereby making patients highly susceptible to recurrent lite threatening bacterial and fungal infections. in this study, we review the medical course of an 8 yr old girl with ar-cgd. she suffered from recurrent dermal and deep abscesses, retractable...

Leishmaniasis is one of the biggest concerns World Health Organization (WHO) due to its severe side effects, emergence resistance, and secondary bacterial infections; therefore, it was reported as an epidemic, especially in immunocompromised individuals. The main purpose this study synthesize characterize polylactic acid (PLA)/chitosan nanofibers decorated with amphotericin B a new delivery sys...

purpose : to introduce a case of cutaneous and lid leishmaniasis in an immune suppressed woman case report : we report an unusual clinical course of old world cutaneous leishmaniasis (owcl) in an immune suppressed 51 years old women recipient of kidney transplant. she developed disseminated cutaneous leishmaniasis (dcl) with bilateral upper and lower eye lids lesions. antimoniate compounds were...

BACKGROUND The Candida species are the most important factors of fungal infections in humans and animals. It is necessary to prepare antifungal or antimicrobial drugs because of increasing drug resistance. The natural treatment of diseases of bacterial origin using medicinal plants is important. In this study the effect of antimicrobial medicinal herbal essential oils and conventional antifunga...

BACKGROUND Surgery is the preferred treatment for hydatid cyst (cystic echinococcosis, CE). At present, various scolicidal agents have been used for inactivation of protoscoleces during surgery, but they are associated with adverse side effects. The aim of the present study was to evaluate the scolicidal effects of amphotricin B, Silver nano particles, Foeniculum vulgare Mill, essential oil and...