نتایج جستجو برای: amorpha
تعداد نتایج: 162 فیلتر نتایج به سال:
As the traditional Chinese medicine, the fresh fruits of Amorpha fruticosa L. were applied for the treatment of carbuncle, eczema and burn (Das et al., 2007). However, little is known about the functional roles of the fruits of Amorpha fruticosa L. during wound healing progress. In the present study, we evaluated both antimicrobial potential against a wide range of microorganisms and wound heal...
Seventeen compounds, including six rotenoids (1-6), seven isoflavones (7-13), one stilbene (14) and three benzoic acid derivatives (15-17) were isolated from the seeds of Amorpha fruticosa. Their structures were elucidated by spectroscopic methods and by comparison of their reported spectral data. Among them, compound 4 was firstly purified as a natural product, compounds 5, 8 12 and 15 17 were...
Amorpha-4,11-diene is the precursor of the antimalarial compound artemisinin. The effect of Vitreoscilla hemoglobin (VHb) and its yeast-conform variant (VHbm) on amorpha-4,11-diene production in engineered Saccharomyces cerevisiae was investigated. First, the VHb gene was mutated to the yeast-conform variant VHbm based on step-by-step extension of a short region of the gene through a series of ...
Malaria, caused by Plasmodium sp, results in almost one million deaths and over 200 million new infections annually. The World Health Organization has recommended that artemisinin-based combination therapies be used for treatment of malaria. Artemisinin is a sesquiterpene lactone isolated from the plant Artemisia annua. However, the supply and price of artemisinin fluctuate greatly, and an alte...
BACKGROUND Artemisinin derivatives are the key active ingredients in Artemisinin combination therapies (ACTs), the most effective therapies available for treatment of malaria. Because the raw material is extracted from plants with long growing seasons, artemisinin is often in short supply, and fermentation would be an attractive alternative production method to supplement the plant source. Prev...
BACKGROUND Production of pharmaceuticals in plants provides an alternative for chemical synthesis, fermentation or natural sources. Nicotiana benthamiana is deployed at commercial scale for production of therapeutic proteins. Here the potential of this plant is explored for rapid production of precursors of artemisinin, a sesquiterpenoid compound that is used for malaria treatment. METHODOLOG...
BACKGROUND Metabolic engineering of cyanobacteria has enabled photosynthetic conversion of CO2 to value-added chemicals as bio-solar cell factories. However, the production levels of isoprenoids in engineered cyanobacteria were quite low, compared to other microbial hosts. Therefore, modular optimization of multiple gene expressions for metabolic engineering of cyanobacteria is required for the...
Arbuscular mycorrhizal fungi (AMF) technology of bioremediation becomes one of the most hotspots in the research on coal-mining subsidence land. This article based on amorpha fruiticosa planting in the mining subsidence of Shendong mining area as a study object, arbuscular mycorrhizal fungi was vaccinated on amorpha fruiticosa after different monitor time, respectively measures are used to anal...
Chicory (Cichorium intybus L.), which is known to have a variety of terpene-hydroxylating activities, was screened for a P450 mono-oxygenase to convert (+)-valencene to (+)-nootkatone. A novel P450 cDNA was identified in a chicory root EST library. Co-expression of the enzyme with a valencene synthase in yeast, led to formation of trans-nootkatol, cis-nootkatol and (+)-nootkatone. The novel enz...
To identify cell cycle-specific ultrastructural markers in acute lymphoblastic leukemia, we labeled bone marrow lymphoblasts with [3H]thymidine, separated them according to cell size by velocity sedimentation at 1 x g, and then identified the pattern of changes within the nucleus of the cells according to phase of the cell cycle. The smallest and most slowly sedimenting cells (probably in G,, p...
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