Aminorex is a cyclic phenylisopropylamine that has been marketed as an anorectic. Despite obvious pharmacological similarities to the amphetamines, little is known about its liability for abuse. In the present study, one group of rhesus monkeys (n = 3) was prepared with intravenous catheters and allowed to self-administer either methohexital or saline in daily experimental sessions. When methoh...

In a retrospective study, we tested the hypothesis that anticoagulant therapy with warfarin sodium (Coumadin) has a beneficial influence on the long-term prognosis in patients with primary pulmonary hypertension (PPH) and aminorex-induced plexogenic pulmonary hypertension. The study included a total of 173 patients from two European cities. One hundred four of these patients took the anorectic ...

Aminorex (2-amino-5-phenyl-2-oxazoline) is an appetite-suppressing drug which was available in Switzerland from November 1965 to October 1968. In 1967 a sudden 20-fold increase in the incidence of primary pulmonary hypertension was observed in a Swiss medical clinic. It was noticed that a considerable number of these patients had taken aminorex to reduce weight. A similar increase in the incide...

The haemodynamic effects of four daily oral doses of 1 5 mg/kg of aminorex (as fumarate) were measured in unanaesthetized beagle dogs. A similar study was performed in another group of related animals using d-amphetamine sulphate (1 mg/kg). Both agents produced similar sympathomimetic effects consisting of transient rises in systemic and pulmonary arterial blood pressures over an eight-hour per...

Pemoline, [(RS)-2-amino-5-phenyl-1,3-oxazol-4(5H)-one] is a central nervous system stimulant used to treat attention-deficit hyperactivity disorder (ADHD) and narcolepsy in humans (Molina and others 1981). In horse racing, pemoline is classified as an Association of Racing Commissioners International (ARCI) ‘Class 1’ foreign substance, i.e., an agent with high potential to influence performance...

conclusions the results of the first human pharmacokinetic studies of aminorex were first characterized in 2013. the results suggest that while humans could produce aminorex from levamisole, they probably do not convert very much. even though cases of pah have been reported in cocaine users, the latest pharmacokinetic studies suggest that very little aminorex is actually produced from the inges...

Reports of pulmonary hypertension in obese women treated with the appetite suppressant aminorex (Menocil) prompted this study using the calf as a model because of its very reactive pulmonary vascular bed. Acute and chronic haemodynamic effects were observed following daily intravenous injections of aminorex (0-25 mg/kg as free base) in four calves. Four other calves were similarly treated with ...

Psychostimulants such as amphetamine and cocaine are illicitly used drugs that act on neurotransmitter transporters for dopamine, serotonin or norepinephrine. These drugs can by themselves already cause severe neurotoxicity. However, an additional health threat arises from adulterant substances which are added to the illicit compound without declaration. One of the most frequently added adulter...

Rats were trained to discriminate 8 mg/kg cocaine from saline vehicle for the purpose of examining the stimulus properties of two novel and structurally related drugs of abuse recently confiscated on the illicit market: (+/-)methcathinone and cis(+/-)4-methylaminorex. The stimulus properties of these controlled substance analogs were compared with those of their parent compounds (+/-)cathinone ...