this study was aimed to investigate the effects of environmental pollution with heavy metals from ferro-nickel smelter on aminolevulinic acid dehydratase (alad) activity, and to analyze the blood lead level of feral pigeon ( columba livia ) in ferro-nickel smelter courtyard in drenas city, republic of kosovo. for this purpose, twenty specimens of feral pigeon (20 birds, males and females), were...

The mold Neurospora crassa does not accumulate porphyrins in iron deficiency but instead accumulates the sideramine desferricoprogen. In iron deficiency there is an accumulation of &aminolevulinic acid and the d-aminolevulinic acid dehydratase level is very low. A similar situation exists in cobalt toxicity and zinc deficiency. The b-aminolevulinic acid synthetase and ferroprotoporphyrin chelat...

In Escherichia coli, Pseudomonas aeruginosa, and Achromobacter metalcaligenes gamma-aminolevulinic acid synthase and gamma-aminolevulinic acid dehydratase appear to be the rate limiting enzymes of porphyrin and heme biosynthesis. Bypassing of these enzymes by addition of gamma-aminolevulinic acid or porphobilinogen results in overproduction of tetrapyrroles.

10. Weissberg, J. B., Lipschutz, F. and Oski, F. A., #{244}-Aminolevulinic acid dehydratase activity in circulating blood cells: A sensitive laboratory test for the detection of childhood lead poisoning. N. Engi. J. Med. 284, 565 (1971). 11. Davis, J. R., and Avrani, M. J., Developmental changes in delta-aminolevulinic acid dehydratase (ALAD) activity and blood reticulocyte percent in the devel...

UNLABELLED OBJECTIVE. The present study was carried out to investigate the effects of occupational lead exposure on the hematological and biochemical parameters in occupationally exposed and non exposed inhabitants of Karachi. MATERIAL AND METHODS. In 100 lead exposed subjects recruited from automobile workshops, lead battery repair and recycling units located in Karachi and in 100 control subj...

In extension of two previous series of experiments, the results of which have been partially reported (1), further long-term tests were performed with daily oral doses of 5 mg Pb++ in 2 subjects. Lead in whole blood, free protoporphyrin 9 (III) and 5-aminolevulinate dehydratase activity in erythrocytes, hemoglobin, and urinary 5-aminolevulinic acid and coproporphyrin III excretion values were m...

Material and Methods: We performed cross-sectional study using 60 workers occupationally exposed to lead compared with 60 controls. All examinees were assessed by Questionnaire, and laboratory testing concerning blood lead level (BLL), activity of delta-aminolevulinic acid dehydratase (ALAD) in blood, concentration of delta-aminolevulinic acid (ALA) and coproporphyrin in urine, reticulocytes an...

5-Aminolevulinic acid dehydratase (ALAD) activity in two patients with compound heterozygous 5-aminolevulinic acid dehydratase deficiency porphyria was studied over the last 20 years. The patients' enzyme activity was <10% from 1977 to 1997. An acute crisis in each patient was successfully treated by infusion of glucose and heme arginate. After this therapy both urinary 5-aminolevulinic acid (A...

T0M0KUNI, K. Effects of Lead Exposure on the Activity of Erythrocyte Pyrimidine 5'-Nucleotidase and s-Aminolevulinic Acid Dehydratase in Mice. Tohoku J. exp. Med., 1983, 139 (1), 27-32 The effects of lead exposure on the activities of erythrocyte pyrimidine 5'-nucleotidase (Py5N) and s-aminolevulinic acid dehydratase (ALA-D) were investigated in the mice given ad libitum the drinking water cont...