نتایج جستجو برای: am281

تعداد نتایج: 56  

Journal: :British journal of anaesthesia 2005
Y Kadoi H Hinohara F Kunimoto H Kuwano S Saito F Goto

INTRODUCTION The purpose of this study was to examine the effects of AM281, a cannabinoid receptor antagonist, on systemic haemodynamics, internal carotid artery blood flow and mortality during septic shock in rats. METHODS The study included three sets of experiments: measurements of changes in systemic haemodynamics and left internal carotid artery flow (30 animals divided into three groups...

2013
G. Vaseghi M. Rabbani V. Hajhashemi

Abrupt cessation of morphine leads to withdrawal signs and cognitive deficits. Endocannabinoid system is activated during withdrawal; therefore, the aim of the present study was to assess the effects of AM281, cannabinoid antagonist/inverse agonist, on memory deficit following spontaneous morphine withdrawal. Cognition was evaluated by using the object recognition task. The novel object recogni...

Journal: :Journal of lipid research 2013
Filippo Molica Fabienne Burger Aurélien Thomas Christian Staub Anne Tailleux Bart Staels Graziano Pelli Andreas Zimmer Benjamin Cravatt Christian M Matter Pal Pacher Sabine Steffens

Percutaneous transluminal angioplasty is frequently used in patients with severe arterial narrowing due to atherosclerosis. However, it induces severe arterial injury and an inflammatory response leading to restenosis. Here, we studied a potential activation of the endocannabinoid system and the effect of FA amide hydrolase (FAAH) deficiency, the major enzyme responsible for endocannabinoid ana...

Journal: :The Journal of clinical investigation 2017
Haixing Zhong Li Tong Ning Gu Fang Gao Yacheng Lu Rou-Gang Xie Jingjing Liu Xin Li Richard Bergeron Lisa E Pomeranz Ken Mackie Feng Wang Chun-Xia Luo Yan Ren Sheng-Xi Wu Zhongcong Xie Lin Xu Jinlian Li Hailong Dong Lize Xiong Xia Zhang

Consciousness can be defined by two major attributes: awareness of environment and self, and arousal, which reflects the level of awareness. The return of arousal after general anesthesia presents an experimental tool for probing the neural mechanisms that control consciousness. Here we have identified that systemic or intracerebral injection of the cannabinoid CB1 receptor (CB1R) antagonist AM...

2012
Angel Arevalo-Martin Daniel Garcia-Ovejero Yolanda Sierra-Palomares Beatriz Paniagua-Torija Ines Gonzalez-Gil Silvia Ortega-Gutierrez Eduardo Molina-Holgado

Spinal cord injury (SCI) induces a cascade of processes that may further expand the damage (secondary injury) or, alternatively, may be part of a safeguard response. Here we show that after a moderate-severe contusive SCI in rats there is a significant and very early increase in the spinal cord content of the endocannabinoids 2-arachidonoylglycerol (2-AG) and arachidonoyl ethanolamide (anandami...

Journal: :Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 2005
Naoshige Harada Kayo Nemoto Tadao Okamura Norifumi Ninomiya Hidenori Suzuki Yasuhiro Yamamoto

OBJECTIVE While endogenous cannabinoids regulate various physiologic functions, their role in the intestinal tract is unclear. We continuously recorded colonic motility in conscious guinea pigs. Mechanisms of action then were investigated using guinea pig taenia caecum in vitro. DESIGN Prospective experimental observations using the cannabinoid agonists 2-arachidonoylglycerol (2-AG) and WIN55...

Journal: :iranian journal of basic medical sciences 0
mohammed rabbani department of pharmacology, isfahan pharmaceutical sciences research centre, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran golnaz vaseghi department of pharmacology, isfahan pharmaceutical sciences research centre, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran valiollah hajhashemi department of pharmacology, isfahan pharmaceutical sciences research centre, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran

objective(s) cannabinoids have been implicated in memory deficit. we examined the effect of am281, cannabinoid antagonist/inverse agonist in prevention of scopolamine-induced cognitive deficit. materials and methods  object recognition task was used to evaluate memory in mice. exploration time in the first and the second trial was recorded. the differences in exploration between a previously se...

2012
Mohammed Rabbani Golnaz Vaseghi Valiollah Hajhashemi

OBJECTIVES Cannabinoids have been implicated in memory deficit. We examined the effect of AM281, cannabinoid antagonist/inverse agonist in prevention of scopolamine-induced cognitive deficit. MATERIALS AND METHODS Object recognition task was used to evaluate memory in mice. Exploration time in the first and the second trial was recorded. The differences in exploration between a previously see...

2011
Alejandra Delgado Erica H. Jaffé

We studied the effects of cannabinoids and acute immobilization stress on the regulation of GABA release in the olfactory bulb. Glutamate-stimulated 3H-GABA release was measured in superfused slices. We report that cannabinoids as WIN55, 212-2, methanandamide, and 2-arachidonoylglycerol were able to inhibit glutamate- and KCl-stimulated 3H-GABA release. This effect was blocked by the CB1 antago...

Journal: :research in pharmaceutical sciences 0
g vaseghi m rabbani v hajhashemi

abrupt cessation of morphine leads to withdrawal signs and cognitive deficits. endocannabinoid system is activated during withdrawal; therefore, the aim of the present study was to assess the effects of am281, cannabinoid antagonist/inverse agonist, on memory deficit following spontaneous morphine withdrawal. cognition was evaluated by using the object recognition task. the novel object recogni...

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