Warfighter exposure to high terrestrial altitude continues to be a reality for the modern fighting force. Understanding the negative effects of altitude on cognitive performance is essential as the cognitive demands of many warfighting tasks are becoming increasingly complex. To date, little research has investigated the performance of multiple cognitive tasks in a high altitude environment. Th...

Suicide, the tenth leading cause of death worldwide, is a complex phenomenon. Models aiming to explain the interaction of ambient variables such as socioeconomic factors, lithium content of drinking water and altitude are poorly developed. While controlling for several risk factors, this research bridges two different, but complementary research lines by investigating statistically the relation...

To investigate the effects of high-altitude exposure on response inhibition, event-related potential (ERP) components N2 and P3 were measured in Go/NoGo task. The participants included an 'immigrant' high-altitude group (who had lived at high altitude for three years but born at low altitude) and a low-altitude group (living in low altitude only). Although the behavioural data showed no signifi...

The hypoxic conditions of extreme altitudes have long been known to have psychological and physiological effects on humans. Such conditions may also impact an individual’s economic valuation and decision-making process relative to non-hypoxic conditions. Building on prior work both in the psychology of economics and the effects of hypoxia on psychology and decision making, this study gathered c...

Exposure to altitude results in multiple physiological consequences. These include, but are not limited to, a reduced maximal oxygen consumption, drop in arterial oxygen saturation, and increase in muscle metabolic perturbations at a fixed sub-maximal work rate. Exercise capacity during fixed work rate or incremental exercise and time-trial performance are also impaired at altitude relative to ...

This study was undertaken to investigate the mechanisms of effects of high altitude on spontaneous and irradiationinduced neoplasia, with particular reference to the influence of the time and duration of high-altitude exposure on the pathogenesis of such growths. Female RF/Un mice exposed to 150 R whole-body Xor sham irradiation at 10 weeks of age were subsequently housed at high (4540 m) or lo...

This study was undertaken to investigate the mechanisms of effects of high altitude on spontaneous and irradiationinduced neoplasia, with particular reference to the influence of the time and duration of high-altitude exposure on the pathogenesis of such growths. Female RF/Un mice exposed to 150 R whole-body Xor sham irradiation at 10 weeks of age were subsequently housed at high (4540 m) or lo...

Exposure to chronic hypoxia during gestation predisposes infants to neonatal pulmonary hypertension, but the underlying mechanisms remain unclear. Here, we test the hypothesis that moderate continuous hypoxia during gestation causes changes in the rho-kinase pathway that persist in the newborn period, altering vessel tone and responsiveness. Lambs kept at 3,801 m above sea level during gestatio...

High-altitude destinations are visited by increasing numbers of children and adolescents. High-altitude hypoxia triggers pulmonary hypertension that in turn may have adverse effects on cardiac function and may induce life-threatening high-altitude pulmonary edema (HAPE), but there are limited data in this young population. We, therefore, assessed in 118 nonacclimatized healthy children and adol...