Abstract   Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurological   disorder with high mortality and morbidity. Some risk factors have been implicated for   ALS such as exposure to high magnetic fields, and trace elements like selenium, cadmium and lead. Afew studies have been carried out throughout the world to evaluate   the prevalence of ALS among veterans. This stud...

amyotrophic lateral sclerosis (als), the most common form of motor neuron disease, is a progressive and devastating disease involving both lower and upper motor neurons, typically following a relentless progression towards death. therefore, all efforts must be made by the clinician to exclude alternative and more treatable entities. als with laboratory abnormalities of uncertain significance is...

abstract   background: amyotrophic lateral sclerosis (als) is a progressive neurological disorder with high mortality and morbidity. some risk factors have been implicated for als such as exposure to high magnetic fields, and trace elements like selenium, cadmium and lead. afew studies have been carried out throughout the world to evaluate the prevalence of als among veterans. this study was ai...

Objective(s): Amyotrophic lateral sclerosis (ALS), a fatal progressive neurodegenerative disorder, is the most common motor neuron disease in European populations. Approximately 10% of ALS cases are familial (FALS) and the other patients are considered as sporadic ALS (SALS). Among many ALS causing genes that have been identified, mutations in SOD1 and C9orf72 are the most common genetic causes...

background: amyotrophic lateral sclerosis (als) is the most common motor neuron disorder in european populations. als can be sporadic als (sals) or familial als (fals). among 20 known als genes, mutations in c9orf72 and superoxide dismutase 1 (sod1) are the most common genetic causes of the disease. whereas c9orf72 mutations are more common in western populations, the contribution of sod1 to al...

Nonnegative matrix factorization (NMF) is a common method in data mining that have been used in different applications as a dimension reduction, classification or clustering method. Methods in alternating least square (ALS) approach usually used to solve this non-convex minimization problem.  At each step of ALS algorithms two convex least square problems should be solved, which causes high com...

amyotrophic lateral sclerosis (als) misdiagnosis has many broad implications for the patient and the neurologist. potentially curative treatments exist for certain als mimic syndromes, but delay in starting these therapies may have an unfavorable effect on outcome. hence, it is important to exclude similar conditions. in this review, we discuss some of the important mimics of als.