equisetum telmateia (equisetaceae) seems to have anti inflammatory and antioxidant properties. in the present study, the neuroprotective effects of organic and inorganic silica were investigated on spinal cord alpha motoneuron of rats after injury of sciatic nerve. after highly compression of sciatic nerve in 42 wistar rats, the injured rats were divided into sham (n= 6) and two experimental gr...

there are extensive evidences that show axonal processes of the nervous system (peripheral and/or central) may be degenerated after nerve injuries. wallerian degeneration and chromatolysis are the most conspicuous phenomena that occur in response to injuries. in this research, the effects of post-operative time following sciatic nerve crush on the number of spinal motoneurons were investigated....

Changes in the presynaptic inhibition of spinal alpha-motoneurons were studied in athletes during motor activities of different types. In the state where muscles were at relative rest, the presynaptic inhibition of spinal alpha-motoneurons of the m. soleus was stronger in muscle samboists (athletes specializing in the martial art of sambo) and sprinters than in long-distance runners. In sambois...

There are extensive evidences that show axonal processes of the nervous system (peripheral and/or central) may be degenerated after nerve injuries. Wallerian degeneration and chromatolysis are the most conspicuous phenomena that occur in response to injuries. In this research, the effects of post-operative time following sciatic nerve crush on the number of spinal motoneurons were investigated....

Paralysis of the soleus muscle in newborn rats causes a large proportion of motoneurons to die by 10 weeks of age. However, all of these neurons are still present at three to four weeks of age. We have previously shown that although nerve injury at five days does not result in any motoneuron death, it does render these neurons susceptible to the toxic effects of the glutamate agonist N-methyl-D...

Morphological alterations and the course of changes in motoneuron counts were studied by light microscopy (cresyl violet staining) in the L2/L3 region of the spinal cord of hemizygotic transgenic rats carrying the amyotrophic lateral sclerosis-associated mutant human gene for Cu,Zn superoxide dismutase (hSOD1G93A) and of their non-transgenic littermates. In 60-day old transgenic rats, a few isc...

The class IV neuronal intermediate filament (IF) family proteins includes the neurofilament (NF) triplet proteins NF-L, NF-M, and NF-H and also the more recently characterized alpha-internexin-NF66. It is well established that NF-L, -M, and -H protein and mRNA are downregulated after peripheral nerve injury. We examined alpha-internexin protein expression after three facial nerve lesion paradig...

The muscle-derived factors required for survival of embryonic motoneurons are not clearly identified. Cardiotrophin-1 (CT-1), a cytokine related to ciliary neurotrophic factor (CNTF), is expressed at high levels in embryonic limb bud and is secreted by differentiated myotubes. In vitro, CT-1 kept 43% of purified E14 rat motoneurons alive for 2 weeks (EC50 = 20 pM). In vivo, CT-1 protected neona...

Motoneurons undergo a phase of target-dependent cell death during development. In chick embryos, motoneuronal death is blocked by the application of the nicotinic antagonists d-tubocurare (dTC) or alpha-bungarotoxin (alpha BTX). Paralytic doses of these drugs also increase intramuscular nerve branch formation. To investigate the possibility that a neuronal rather than a muscle-type nicotinic AC...