alpha-fetoprotein (afp), a serum glycoprotein belonging to the onco-developmental proteins group, serves as a marker both in cancer research and in studies concerning fetal development and fetal pathophysiology. monoclonal anti-afp antibodies are essential reagents in developing appropriate techniques for measurement of this protein. in this study, in order to produce anti-afp monoclonal antibo...

background: prediction of severe neonatal hyperbilirubinemia is very important for early treatment and prophylaxis of neurologic sequels. the aim of this study was to evaluate the predictive role of umbilical cord ^5-fetoprotein (ucafp) as a marker of an increased risk for neonatal hyperbilirubinemia in full term babies. methods: umbilical cord blood was collected from 400 term singleton full t...

Screening examination for maternal, especially serum, is a non-invasive of the fetus’s condition. During pregnancy, screening examinations are performed in women recommended ultrasonography (USG), amniocentesis, or other obstetric interventions. There three markers maternal serum screening: alpha-fetoprotein, human chorionic gonadotropin (hCG), and unconjugated estriol. Maternal alpha-fetoprote...

Alpha-fetoprotein is an oncofetal protein the embryo produces during fetal development. The serves two critical functions simultaneously: it delivers nutrients to growing cells and immature myeloid-derived suppressor cells, so mother’s immune system doesn’t attack embryo. present in minuscule amounts adults elevated alpha-fetoprotein levels serve as pregnancy or tumor markers. Exogenous has a n...

Alpha-fetoprotein is a well-known tumor marker in the screening and follow-up of hepatocellular carcinoma. In Taiwanese society, a high prevalence of hepatitis and hepatoma and elevation of alpha-fetoprotein associated with liver function impairment usually suggested clinics undertake further examination for liver or genital tumor. We report the case of 45-year-old man who was found to have an ...

We have explored immobilized metal affinity chromatography as a means of resolving alpha-fetoprotein from its homologous albumin, a problem perennially encountered in the purification of an alpha-fetoprotein or its detection. Human alpha-fetoprotein and human serum albumin were chromatographed on immobilized iminodiacetic acid charged with either Co2+, Ni2+, Cu2+, or Zn2+. Neither human alpha-f...