The optimized geometries, harmonic vibrational frequencies, and energies of the structures of monohydrated alloxan were computed at the DFT/ωB97X-D and B3LYP/6-311++G** level of theory. Results confirm that the monohydrate exists as a dipolar alloxan-water complex which represents a global minimum on the potential energy surface (PES). Trajectory dynamics simulations show that attempt to reorie...

the present study was carried out to determine the hypoglycemic activity of the methanolic extract and solvent fractions (n-hexane and ethyl acetate) of ruellia tuberosa in normal and alloxan-induced diabetic rabbits. optimum dose of r. tuberosa for hypoglycemic activity was determined by oral administration of the methanolic extract (me) to normal and diabetic rabbits. diabetes was induced by ...

background: combinatorial effects of aqueous root extract of jatropha curcas (jc) and j. gossypiifolia (jg) in alloxan-induced diabetic rats was investigated in this research. methods: thirty-six wistar rats were randomized into six groups of six animals each. group i (control) was not induced but received 0.5 ml of distilled water. groups ii, iii, iv, v and vi were induced with diabetes mellit...

Background: Combinatorial effects of aqueous root extract of Jatropha curcas (Jc) and J. gossypiifolia (Jg) in alloxan-induced diabetic rats was investigated in this research. Methods: Thirty-six wistar rats were randomized into six groups of six animals each. Group I (control) was not induced but received 0.5 ml of distilled water. Groups II, III, IV, V and VI were induced with diabetes mel...

Administration of aqueous extracts of V. rosea flower and leaf have been found to regulate the blood sugar level in alloxan diabetic male albino rats. V. rosea therapy not only produced blood glucose homeostasis but also reversed changes in carbohydrate, protein, lipid metabolisms and metabolic and pathologic changes that took place in pancreatic islet cells, liver and kidney following a single...

Background/Objectives: Diabetes mellitus impairs glucose homeostasis causing neurological disorders due to perturbation in utilization of glucose. The mechanisms responsible for failure of glycaemic control in diabetes need to be thoroughly elucidated and hence the present study was initiated. Material and Methods: Diabetes was induced in albino rat models with alloxan monohydrate (40 mg/Kg int...

BACKGROUND Diabetes mellitus has remained a significant contributor to morbidities and mortalities in our environment despite all efforts to curb the trend. Regrettably, conventional, orthodox hypoglycemic agents have remained unaffordable. Consequently the need for available and affordable alternatives cannot be overemphasized. OBJECTIVES To determine the effect of the methanolic seed extrac...

In most nations, diabetes mellitus is a serious and rising health issue. The goal of the study was to compare antidiabetic effects leaves extracts Decalepis hamiltonii in normal diabetic rats induced with alloxan. Using 120 mg/kg alloxan monohydrate, induced. order considerably lower blood glucose levels both alloxan-induced rats, D. methanolic extract given at doses 200 mg 400 mg, along gliben...