AIM The aim of this discursive paper is to introduce allostasis and allostatic load, which are relatively new concepts proposed to explain physiological responses to stress, and to suggest ways in which allostasis theory can be applied to the development of clinical interventions to increase resilience for producing better health outcome. BACKGROUND Common explanations of stress have failed a...

The purpose of the book is to introduce the concept of allostasis to the reader and to place it within the context of traditional conceptions of homeostasis. Both these regulatory conceptions – homeostasis and allostasis – are broadly conceived within biological adaptations in which behavior and physiology figure prominently. It is within this context of biological adaptation that regulation of...

The concept of homeostasis, the maintenance of the internal physiological environment of an organism within tolerable limits, is well established in medicine and physiology. In contrast, allostasis is a relatively new idea. Allostasis explains how regulatory events maintain organismic viability, or not, in diverse contexts with varying setpoints of bodily needs and competing motivations. Allost...

Critical to survival is the geriatric concept, allostasis, defined as the ability to achieve stability through change. It is appropriate that allostasis is an introduction to this commentary, which may partially apply to the medical and pharmacy profession as currently constituted.

The recently-described Stress Repair Mechanism (SRM) automatically repairs and maintains vertebrate body structure, but it lacks the ability to adjust to changing environmental circumstances. Therefore its operation cannot explain allostasis, which refers to the ability of vertebrates to adapt to changing environmental allostatic load by altering their hormonal and physiological reactions. Allo...

Organizational excellence is critical towards the development of organizations and, considering organizations’ role in modern world, for societies’ economic and social development. The ability to adapt adjust contingencies change recover stability organizational systems through own dynamic process known as allostasis. This research focuses on relationship between allostasis excellence. Based a ...

Homeostasis is the basis of modern medicine and allostasis, a further elaboration of homeostasis, has been defined as stability through change, which was later modified to predictive reference resetting. It has been suggested that pleasure is related to salience (behavioral relevance), and withdrawal has been linked to allostasis in addictive types. The question arises how the clinical and neur...

OBJECTIVE One of the signals for the beta-cell to maintain an adequate response to worsening insulin sensitivity is elevated ambient glycemia, namely the concept of "glucose allostasis." We examined whether glucose allostasis can be demonstrated using oral glucose tolerance tests (OGTTs) and the effects of the dynamics of beta-cell demand on longitudinal changes of glucose tolerance in obese yo...