allergic fungal sinusitis (afs) has been clinicopathologically defined as a noninvasive form of fungal infection. this study was designed to distinguish afs among patients with chronic sinusitis who failed to respond to repeated courses of antibiotics and were therefore candidates for functional endoscopic sinus surgery (fess) in sari. allergic mucin and sinus lavage was collected during fess f...

background: black seed (bs) is used in traditional medicine as a therapy for a variety of diseases including allergic asthma. materials and methods: in the present study, anti-inflammatory and immunomodulatory effects of bs on cytokine gene expression, lung airway eosinophilia and goblet cell hyperplasia were examined in a mouse mice model of allergic asthma. groups of 6-week-old female balb/c ...

Allergic mucin is described as thick, peanut butter-like mucus impacted in the paranasal sinuses of patients with allergic fungal rhinosinusitis. The presence of allergic mucin in the middle ear has never been reported. We encountered a 65-year-old female with allergic mucin found impacted in her left middle ear and mastoid cavity during revised tympanoplasty surgery at our institute. Bilateral...

The original hygiene hypothesis suggests that early childhood respiratory infections preceding allergen exposure may decrease the prevalence of allergic diseases. We have recently demonstrated that Mycoplasma pneumoniae infection preceding allergen exposure reduced allergic responses in mice. However, the molecular mechanisms underlying the protective role of M. pneumoniae in allergic responses...

background: allergic fungal sinusitis is a non-invasive disease, and accounts for approximately 6-8% of all chronic sinusitis requiring surgical intervention. as the treatment and prognosis of these disorders vary significantly, it is extremely important to recognize allergic fugal sinusitis and differentiate it from chronic sinusitis of bacterial and fungal origin. this prospective study evalu...

Background: Allergic fungal sinusitis is a non-invasive disease, and accounts for approximately 6-8% of all chronic sinusitis requiring surgical intervention. As the treatment and prognosis of these disorders vary significantly, it is extremely important to recognize allergic fugal sinusitis and differentiate it from chronic sinusitis of bacterial and fungal origin. This prospective study evalu...

Allergic fungal sinusitis (AFS) is a noninvasive form of fungal rhinosinusitis with an incidence of between 6 and 9% of all rhinosinusitis requiring surgery. Regional variation in incidence has been reported, with the southern and southwestern US particularly endemic. Patients with AFS commonly present with chronic rhinosinusitis with nasal polyps, inhalant atopy, elevated total serum immunoglo...

we present a case of allergic fungal sinusitis (afb) in a 20-year old man with few months' history of bilateral nasal obstruction and discharge with unilateral proptosis that underwent maxillary antrostomy due to the mass in paranasal sinuses. histological examination of tissue showed branching fungal hyphae interspersed with allergic mucin without fungal invasion to soft tissue. the patient re...

Allergic asthma is characterized by airway eosinophilia, increased mucin production and allergen-specific IgE. Fc gamma receptor IIb (FcgammaRIIb), an inhibitory IgG receptor, has recently emerged as a negative regulator of allergic diseases like anaphylaxis and allergic rhinitis. However, no studies to date have evaluated its role in allergic asthma. Our main objective was to study the role of...

BACKGROUND Protective host responses to respiratory pathogens are typically characterized by inflammation. However, lung inflammation is not always protective and it may even become deleterious to the host. We have recently reported substantial protection against Streptococcus pneumoniae (pneumococcal) pneumonia by induction of a robust inflammatory innate immune response to an inhaled bacteria...