The Nrf2 (NFE2L2) cell defense pathway protects against oxidative stress and disorders including cancer and neurodegeneration. Although activated modestly by oxidative stress alone, robust activation of the Nrf2 defense mechanism requires the additional presence of co-factors that facilitate electron exchange. Various molecules exhibit this co-factor function, including sulforaphane from crucif...

We have used fast time-resolved infrared spectroscopy to characterize a series of organometallic methane and ethane complexes in solution at room temperature: W(CO)5(CH4) and M(eta5-C5R5)(CO)2(L) [where M = Mn or Re, R = H or CH3 (Re only); and L = CH4 or C2H6]. In all cases, the methane complexes are found to be short-lived and significantly more reactive than the analogous n-heptane complexes...

Three-component couplings were achieved from common aryl halides, alkyl halides, and heteroarenes under palladium and norbornene co-catalysis. The reaction forges hindered aryl-heteroaryl bonds and introduces ortho-alkyl groups to aryl rings. Various heterocycles such as oxazoles, thiazoles and thiophenes underwent efficient coupling. The heteroarenes were deprotonated in situ by bases without ...

sio2-supported silyl chromate catalyst is an important industrial catalyst for production of high grade hdpepipe materials. the control of the short chain branch (scb) distribution using this catalyst system is still a greatchallenge. in this work, ethylene and 1-hexene copolymers were synthesized using sio2-supported silyl chromatecatalyst combined with triisobutylaluminium (tiba), triethylalu...

A MnI-catalyzed hydroboration of terminal alkenes and a 1,2-diboration alkynes with pinacolborane (HBPin) is described. For alkenes, anti-Markovnikov takes place; for the reaction proceeds excellent trans-1,2-selectivity. The most active pre-catalyst bench-stable alkyl bisphosphine MnI complex fac-[Mn(dippe)(CO)3(CH2CH2CH3)]. catalytic process initiated by migratory insertion CO ligand into Mn–...

The nickel-catalyzed cross-coupling of aryl halides with alkyl radicals derived from alkyl halides has recently been extended to couplings with carbon radicals generated by a co-catalyst. In this study, a new co-catalyst, cobalt phthalocyanine (Co(Pc)), is introduced and demonstrated to be effective for coupling substrates not prone to homolysis. This is because Co(Pc) reacts with electrophiles...

Square planar dialkyl complexes of nickel, palladium and platinum exhibit intriguing difference in their reactivities. Thermolysis pathways of these dialkyls vary depending on the metal, ligands, alkyl groups, geometry as well as the presence or absence of added ligand. Kinetic studies on the thermolysis and trans-cis isomerizations of PdR,L2 (L = tertiary phosphine) complexes showed involvemen...

Cobalt(II) compounds [Co(C10C8C2-terpy)2](BF4)2 (1) and [Co(C12C10C2terpy)2](BF4)2 (2) (CxCyCz-terpy = 4’-5’’’-Alkyl-1’’’-alkoxy-2,2’:6’,2’’-terpyridine) with branched alkyl chains, based on a terpyridine frame, were synthesized. The cobalt(II) compounds 1 and 2 exhibit the spin transition between low-spin and high-spin with thermal hysteresis loop at the liquid crystal transition temperature (...