Control of the midgut pH in Lutzomyia longipalpis enables the insect's digestive system to deal with different types of diet. Phlebotomines must be able to suddenly change from a condition adequate to process a sugar diet to one required to digest blood. Prior to blood ingestion, the pH in the midgut is maintained at ∼6 via an efficient mechanism. In the abdominal midgut, alkalization to a pH o...

stomatal closure are accompanied by cytosolic alkalization in guard cells. However, it remains to be clarifi ed how the alkalization functions in not only ABA signaling but also MeJA. We investigated cytosolic alkalization in guard cells during ABA-, MeJAand Ca 2 + -induced stomatal closure of wild type, abi1-1 , abi2-1 , ost1-2 and coi1 using a pHsensitive fl uorescent dye, BCECF-AM. ABA induc...

It is reported here that salicylic acid (SA) is rapidly taken up by Arabidopsis cells, and its uptake is accompanied by media alkalization and cytosolic acidification, and it is inhibited by the ionophore nigericin, suggesting that its import is linked with that of H+ and driven by a proton gradient. Such import and accumulation declined sharply within a narrow physiological pH range (pH 5.7-6....

External alkalization activates the Rim101 pathway in Saccharomyces cerevisiae. In this pathway, three integral membrane proteins, Rim21, Dfg16, and Rim9, are considered to be the components of the pH sensor machinery. However, how these proteins are involved in pH sensing is totally unknown. In this work, we investigated the localization, physical interaction, and interrelationship of Rim21, D...

Transient alkalization caused by activation of the BK(Ca) channels has been reported to be essential for the activation of proteolytic enzymes and bacterial killing in the leukocytic phagosomes. We investigated the effects of high glucose concentrations on these processes in THP-1 cells. While E. coli transiently raised the pH of the phagosomes in THP-1 monocytes, high glucose concentrations im...

The re-alkalization technology of carbonated concrete can effectively restore the alkalinity concrete, but effect is affected by many factors, such as voltage, electrolyte concentration, and current conduction time. In this paper, under different parameter changes studied, feasibility selection range parameters in its application are determined. Results show that voltage should be controlled be...

The effect of combining therapy with hydrochlorothiazide, allopurinol and systemic alkalization for urolithiasis with lower urinary pH was examined. A total of 90 patients were followed up for 1 to 3 years, the average follow up period being 18 months. The total stone disappearance rate was 60% (kidney stone), 74% (ureter stone) and 20% (bladder stone). Large amounts of thiazide diuretics, pota...