Canonical primary microRNA (miRNA) transcripts and mirtrons are proposed to transit distinct nuclear pathways en route to generating mature approximately 22 nucleotide regulatory RNAs. We generated a null allele of Drosophila pasha, which encodes a double-stranded RNA-binding protein partner of the RNase III enzyme Drosha. Analysis of this mutant yielded stringent evidence that Pasha is essenti...

Drosha is a type III RNase, which plays a critical role in miRNA biogenesis. Drosha and its double-stranded RNA-binding partner protein Pasha/DGCR8 likely recognize and cleave miRNA precursor RNAs or pri-miRNA hairpins cotranscriptionally. To identify RNAs processed by Drosha, we used tiling microarrays to examine transcripts after depletion of drosha mRNA with dsRNA in Drosophila Schneider S2 ...

Success rate group search optimiser Mohammad Hasanzadeh, Sana Sadeghi, Alireza Rezvanian & Mohammad Reza Meybodi To cite this article: Mohammad Hasanzadeh, Sana Sadeghi, Alireza Rezvanian & Mohammad Reza Meybodi (2016) Success rate group search optimiser, Journal of Experimental & Theoretical Artificial Intelligence, 28:1-2, 53-69, DOI: 10.1080/0952813X.2014.971467 To link to this article: http...

The Program Archive on Sexuality, Health & Adolescence (PASHA) identifies programs aimed at preventing pregnancies and sexually transmitted diseases among teenagers, and makes materials from interventions with demonstrated effectiveness available to practitioners around the country. With the assistance of a panel of experts, PASHA has identified an initial group of 15 pregnancy prevention and 1...

The microRNA (miRNA) processing pathway produces miRNAs as posttranscriptional regulators of gene expression. The nuclear RNase III Drosha catalyzes the first processing step together with the dsRNA binding protein DGCR8/Pasha generating pre-miRNAs [1, 2]. The next cleavage employs the cytoplasmic RNase III Dicer producing miRNA duplexes [3, 4]. Finally, Argonautes are recruited with miRNAs int...

So the story goes, in the late 1980s, the Turkish general Kenan Evren, who led the 1980 coup d’etat in Turkey, encountered the popular Turkish music icon known widely as ‘the Pasha of Art’, Zeki Müren, who was a much respected performer – well-known for his extravagant costumes on stage and his mannered queer performance. This encounter was followed by a conversation initiated by the general’s ...

mirza malkum khan nazem al-dowleh, the famous iranian thinker and politician of the nineteenth century, spent about ten years in the ottoman empire during the period of tanzimat and was associated with important figures in tanzimat and the first ottoman constitutional era such as foad pasha, aali pasha and medhat pasha. later, he claimed that he had written the important tanzimats figure, foad ...

Jafari-Shakib Reza, Rafiei Alireza, Ansari Mostafa, Khalilian Alireza, Hajilooi Mehrdad Department of Immunology and Microbiology, Rasht Medical School, Guilan University of Medical Sciences, Rasht; Cellular and Molecular Biology Research Center, Sari Medical School, Mazandaran University of Medical Sciences, Sari; Department of Internal Medicine, Ekbatan Hospital, Medical School, University of...

An efficient oscillating inertia weight of particle swarm optimisation for tracking optima in dynamic environments Javidan Kazemi Kordestani, Alireza Rezvanian & Mohammad Reza Meybodi To cite this article: Javidan Kazemi Kordestani, Alireza Rezvanian & Mohammad Reza Meybodi (2016) An efficient oscillating inertia weight of particle swarm optimisation for tracking optima in dynamic environments,...